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正常和突变B淋巴细胞中II类相关恒定链基因的调控。

Regulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes.

作者信息

Doyle C, Ford P J, Ponath P D, Spies T, Strominger J L

机构信息

Division of Tumor Virology, Dana-Farber Cancer Institute, Boston, MA 02115.

出版信息

Proc Natl Acad Sci U S A. 1990 Jun;87(12):4590-4. doi: 10.1073/pnas.87.12.4590.

DOI:10.1073/pnas.87.12.4590
PMID:2112745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC54162/
Abstract

The invariant chain protein is intracellularly associated with class II major histocompatibility proteins. In many cases, the expression of these molecules appears to be regulated in a similar manner. Contained within the promoter of the invariant chain gene are sequences (X and I gamma 1) that are similar to the X and Y box elements of class II genes, suggesting that these sequences might be involved in its regulation. DNase I footprinting reveals additional cis-acting elements (I gamma 2 and I gamma 3) that contain sequence similarities to NF-kappa B and/or H2TF1/KBF1 recognition sequences. A series of fusion constructs with the chloramphenicol acetyltransferase reporter gene were used to analyze the role of these sequences (I gamma 1, I gamma 2, I gamma 3, and X and Y elements) in both normal and mutant B lymphocytes. These data suggest the likelihood of multiple X box proteins in B cells, which can act as both negative and positive regulatory factors.

摘要

恒定链蛋白在细胞内与II类主要组织相容性蛋白相关联。在许多情况下，这些分子的表达似乎以类似的方式受到调节。恒定链基因的启动子中包含与II类基因的X和Y盒元件相似的序列（X和Iγ1），这表明这些序列可能参与其调节。DNase I足迹分析揭示了另外的顺式作用元件（Iγ2和Iγ3），它们包含与NF-κB和/或H2TF1/KBF1识别序列相似的序列。一系列带有氯霉素乙酰转移酶报告基因的融合构建体被用于分析这些序列（Iγ1、Iγ2、Iγ3以及X和Y元件）在正常和突变B淋巴细胞中的作用。这些数据表明B细胞中存在多种X盒蛋白的可能性，它们可作为负性和正性调节因子发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/46e8ff9c200f/pnas01037-0189-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/9e905dc96aba/pnas01037-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/3e27199a79c0/pnas01037-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/46e8ff9c200f/pnas01037-0189-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/9e905dc96aba/pnas01037-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/3e27199a79c0/pnas01037-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/54162/46e8ff9c200f/pnas01037-0189-b.jpg

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本文引用的文献

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Structure of Ia antigens: identification of dimeric complexes formed by the invariant chain.Ia抗原的结构：由恒定链形成的二聚体复合物的鉴定
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
CCAAT结合因子NF-Y和RFX是体内组装跨越250个碱基对的核蛋白复合物所必需的：以恒定链启动子为模型。
Mol Cell Biol. 1997 Aug;17(8):4589-96. doi: 10.1128/MCB.17.8.4589.
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Current concepts in DRA gene regulation.DRA基因调控的当前概念。
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Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.在通过γ干扰素诱导主要组织相容性复合体II类基因方面存在缺陷的突变人类细胞。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2880-4. doi: 10.1073/pnas.90.7.2880.
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Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.人类组织相容性白细胞抗原II类表达和抗原呈递在裸淋巴细胞综合征中的协同缺陷。
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