Department of Endocrinology, Leicester Royal Infirmary, Victoria Building, Leicestershire, LE1 5WW, UK.
Curr Neurol Neurosci Rep. 2011 Apr;11(2):164-70. doi: 10.1007/s11910-010-0166-7.
Pituitary tumors may give rise to headache via numerous mechanisms. The traditional explanation for headache is dural stretch and cavernous sinus invasion, although this is not borne out by clinical studies. Certain functional pituitary tumors are associated with headache, notably growth hormone and prolactin-secreting tumors. The observation that somatostatin analogues can have a dramatic analgesic effect in acromegaly suggests that biochemical properties of the tumor may be important. The genetic predisposition of the patient to primary headache also determines whether headache occurs with pituitary tumors. This article attempts to outline the clinical features, management strategies, and key academic questions regarding the subject of pituitary tumors and headache.
垂体肿瘤可能通过多种机制引起头痛。传统的头痛解释是硬脑膜拉伸和海绵窦侵犯，但这并没有被临床研究证实。某些功能性垂体肿瘤与头痛有关，特别是生长激素和催乳素分泌性肿瘤。生长抑素类似物在肢端肥大症中具有显著的镇痛作用的观察结果表明，肿瘤的生化特性可能很重要。患者对原发性头痛的遗传易感性也决定了是否会发生垂体肿瘤头痛。本文试图概述与垂体肿瘤和头痛相关的临床特征、管理策略和关键学术问题。
