Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Expert Rev Respir Med. 2010 Dec;4(6):773-83. doi: 10.1586/ers.10.71.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negative bacteria, has been used to induce ALI/ARDS. LPS-induced animal models highlight ways to explore mechanisms of multiple diseases and provide useful information on the discovery of novel biomarkers and drug targets. However, each model has its own merits and drawbacks. The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated. Advantages and disadvantages of such models in pulmonary research and new directions for future investigations are also discussed.
急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是一种以肺水肿和急性炎症为特征的综合征。脂多糖（LPS）是革兰氏阴性菌的主要成分，已被用于诱导 ALI/ARDS。LPS 诱导的动物模型突出了探索多种疾病机制的方法，并为新型生物标志物和药物靶点的发现提供了有用信息。然而，每种模型都有其自身的优点和缺点。本文的目的是总结和评估 LPS 诱导的 ALI/ARDS 的实验结果，并阐明可能的机制和治疗方法。还讨论了此类模型在肺部研究中的优缺点以及未来研究的新方向。
