Friedlander Elizabeth A, Pallentino Julia, Miller Sally K, VanBeuge Susan S
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
J Am Acad Nurse Pract. 2010 Dec;22(12):674-83. doi: 10.1111/j.1745-7599.2010.00578.x. Epub 2010 Nov 24.
This article reviews the diagnosis and current treatment options for gastroesophageal reflux disease (GERD) available to nurse practitioners, with a focus on advances in proton pump inhibitor (PPI) therapy.
Review of scientific literature and clinical management guidelines for GERD treatment and PPI therapy from the PubMed database, Google Scholar, and other World Wide Web resources.
A number of safe and effective treatment options exist for GERD. Recent developments in PPI technology may begin to address unmet needs in PPI therapy.
GERD is commonly diagnosed and treated by nurse practitioners in the primary care setting. Acid suppression therapy is the primary medical therapy for GERD. PPI therapy provides symptomatic relief of heartburn and regurgitation, as well as effective healing and maintenance of erosive esophagitis. Newer PPIs lengthen the duration of acid suppression and allow for more flexibility in dosing, which may improve medication adherence and decrease episodes of acid breakthrough.
本文综述了执业护士可采用的胃食管反流病（GERD）的诊断方法及当前治疗方案，重点关注质子泵抑制剂（PPI）治疗的进展。
对来自PubMed数据库、谷歌学术及其他万维网资源的GERD治疗和PPI治疗的科学文献及临床管理指南进行综述。
GERD有多种安全有效的治疗方案。PPI技术的最新进展可能开始满足PPI治疗中未得到满足的需求。
GERD在初级保健环境中通常由执业护士进行诊断和治疗。抑酸疗法是GERD的主要药物治疗方法。PPI治疗可缓解烧心和反流症状，有效治愈并维持糜烂性食管炎。新型PPI延长了抑酸持续时间，给药更灵活，这可能提高药物依从性并减少酸突破发作。
