Harrop-Griffiths A W, Watson N A, Jewkes D A
Department of Anaesthesia, National Hospital for Nervous Diseases, London.
Br J Anaesth. 1990 May;64(5):586-9. doi: 10.1093/bja/64.5.586.
A technique is described for the anaesthetic management of trigeminal nerve thermocoagulation by administration of repeated doses of midazolam and flumazenil. "Wake-up" times after administration of flumazenil in 20 patients were shorter than those reported during spontaneous recovery from methohexitone or propofol anaesthesia. The midazolam dose required for a second phase of sedation after antagonism of the first with flumazenil was significantly less than that for the first phase of sedation. There was no evidence of postoperative resedation. Reversal of sedation was associated with an increase in arterial pressure.
描述了一种通过重复给予咪达唑仑和氟马西尼来进行三叉神经热凝术麻醉管理的技术。20例患者给予氟马西尼后的“苏醒”时间比甲己炔巴比妥或丙泊酚麻醉后自然恢复过程中报告的时间短。用氟马西尼拮抗第一阶段镇静后，第二阶段镇静所需的咪达唑仑剂量明显少于第一阶段镇静所需剂量。没有术后再镇静的证据。镇静的逆转与动脉压升高有关。
