Kyttä J, Rosenberg P H
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Anaesthesia. 1988 Mar;43 Suppl:50-3. doi: 10.1111/j.1365-2044.1988.tb09070.x.
Propofol and methohexitone given in equipotent doses were compared for anaesthesia for thermocoagulation of trigeminal rootlets. Thirty-eight patients received two to six injections of the induction agents in one therapy session. The increase in arterial blood pressure during coagulation was significantly lower in the propofol group. Respiratory problems were encountered more often in those who received methohexitone (7/19 patients) than propofol (2/19 patients). There was a small but significant increase in blood propofol concentrations as well as in methohexitone plasma concentrations after repeated injections. Individual wake-up times increased to a statistically significant extent in relation to the number of doses of the induction agent but the increases were clinically unimportant (maximal mean change approximately 2 minutes). There were no differences in wake-up times between the two anaesthetic groups.
比较了等剂量的丙泊酚和甲己炔巴比妥用于三叉神经根热凝术麻醉的效果。38例患者在一次治疗过程中接受了2至6次诱导剂注射。丙泊酚组在凝血过程中动脉血压的升高明显较低。接受甲己炔巴比妥的患者（7/19例）比接受丙泊酚的患者（2/19例）更常出现呼吸问题。重复注射后，丙泊酚血药浓度以及甲己炔巴比妥血浆浓度均有小幅但显著的升高。个体苏醒时间随诱导剂剂量的增加有统计学意义的延长，但这种延长在临床上并不重要（最大平均变化约2分钟）。两组麻醉患者的苏醒时间没有差异。
