Tancer M E, Stein M B, Uhde T W
Section on Anxiety and Affective Disorders, National Institute of Mental Health, Bethesda, MD 20892.
Biol Psychiatry. 1990 Jun 1;27(11):1227-30. doi: 10.1016/0006-3223(90)90420-7.
Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the rate of positive GH responses to TRH in 38 patients with panic disorder and 23 normal controls. There were no between-group differences in mean GH response to TRH or in the proportion of subjects with positive responses. These findings are discussed in the context of neuroendocrine regulation of GH secretion and the relationship between anxiety and affective disorders.
据报道，促甲状腺激素释放激素（TRH）在多种病理状态下可刺激生长激素（GH）释放，包括一些关于重度抑郁症的研究。由于重度抑郁症和惊恐障碍在现象学和神经内分泌方面存在相当大的重叠，我们研究了38例惊恐障碍患者和23名正常对照者对TRH产生阳性GH反应的比率。两组之间在对TRH的平均GH反应或阳性反应受试者的比例方面没有差异。将在GH分泌的神经内分泌调节以及焦虑与情感障碍之间的关系背景下讨论这些发现。
