Rapaport M H, Risch S C, Gillin J C, Golshan S, Janowsky D S
Department of Psychiatry, University of California, San Diego, La Jolla.
Am J Psychiatry. 1989 Jan;146(1):92-5. doi: 10.1176/ajp.146.1.92.
Patients with panic disorder (N = 11) and age- and sex-matched normal control subjects (N = 11) were challenged with human growth hormone-releasing factor (GH-RF) (1 microgram/kg i.v.) or placebo in random order. The control subjects had significantly increased plasma growth hormone (GH) levels after GH-RF infusion whereas panic disorder patients did not. At 15 and 30 minutes after GH-RF infusion, GH concentrations were significantly higher in the control subjects than in the patients. These findings with GH-RF extend findings from earlier reports that patients with panic disorder show blunted GH response to phobic stimulation and clonidine.
惊恐障碍患者（N = 11）以及年龄和性别匹配的正常对照受试者（N = 11），被随机给予人生长激素释放因子（GH - RF）（1微克/千克静脉注射）或安慰剂进行激发试验。在输注GH - RF后，对照受试者的血浆生长激素（GH）水平显著升高，而惊恐障碍患者则没有。在输注GH - RF后的15分钟和30分钟，对照受试者的GH浓度显著高于患者。这些关于GH - RF的研究结果扩展了早期报告中的发现，即惊恐障碍患者对恐惧刺激和可乐定的GH反应减弱。
