Baiker K, Scurrell E, Wagner T, Walker D, Solano-Gallego L, Holt E, Smyth B, Summers B A, Schöniger S
Department of Pathology and Infectious Diseases, UK.
J Comp Pathol. 2011 May;144(4):317-23. doi: 10.1016/j.jcpa.2010.10.006. Epub 2010 Dec 3.
A male Jack Russell terrier developed bilateral uveitis and glaucoma at 1 year of age. Since the ocular disease was painful and unresponsive to treatment, both globes were enucleated. Microscopical evaluation of one enucleated globe revealed panuveitis, with pigment dispersion and phagocytosis consistent with the ocular lesions of canine Vogt-Koyanagi-Harada (VKH)-like syndrome. Three years later the dog was represented with severe muscle disease and skin lesions. Due to rapid clinical deterioration the dog was humanely destroyed. Necropsy examination revealed lichenoid interface inflammation in the skin and mucous membranes, with pigmentary incontinence consistent with VKH-like syndrome and lymphocytic and histiocytic polymyositis with marked muscle atrophy. Canine VKH-like syndrome is an autoimmune disease that targets melanocyte antigens. Some human patients with VKH disease develop additional autoimmune diseases. To our knowledge this is the first reported case of polymyositis subsequent to VKH-like disease in a dog. In addition, VKH-like disease has not been previously reported in a Jack Russell terrier.
一只雄性杰克罗素梗犬在1岁时出现双侧葡萄膜炎和青光眼。由于眼部疾病疼痛且对治疗无反应，两只眼球均被摘除。对一只摘除的眼球进行显微镜检查发现全葡萄膜炎，伴有色素分散和吞噬现象，与犬类Vogt - 小柳 - 原田（VKH）样综合征的眼部病变一致。三年后，这只狗出现严重的肌肉疾病和皮肤病变。由于临床病情迅速恶化，这只狗被实施安乐死。尸检发现皮肤和黏膜有苔藓样界面炎症，伴有与VKH样综合征一致的色素失禁，以及淋巴细胞和组织细胞性多肌炎并伴有明显的肌肉萎缩。犬类VKH样综合征是一种针对黑素细胞抗原的自身免疫性疾病。一些患有VKH病的人类患者会出现其他自身免疫性疾病。据我们所知，这是首例报道的犬类VKH样疾病继发多肌炎的病例。此外，此前尚未有杰克罗素梗犬发生VKH样疾病的报道。
