Lindenboim Liora, Borner Christoph, Stein Reuven
Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Ramat Aviv, Israel.
Biochim Biophys Acta. 2011 Apr;1813(4):584-96. doi: 10.1016/j.bbamcr.2010.11.016. Epub 2010 Dec 2.
An important mechanism in apoptotic regulation is changes in the subcellular distribution of pro- and anti-apoptotic proteins. Among the proteins that change in their localization and may promote apoptosis are nuclear proteins. Several of these nuclear proteins such as p53, Nur77, histone H1.2, and nucleophosmin were reported to accumulate in the cytosol and/or mitochondria and to promote the mitochondrial apoptotic pathway in response to apoptotic stressors. In this review, we will discuss the functions of these and other nuclear proteins in promoting the mitochondrial apoptotic pathway, the mechanisms that regulate their accumulation in the cytosol and/or mitochondria and the potential role of Bax and Bak in this process. This article is part of a Special Issue entitled Mitochondria: the deadly organelle.
凋亡调控中的一个重要机制是促凋亡蛋白和抗凋亡蛋白在亚细胞分布上的变化。在定位发生改变且可能促进凋亡的蛋白中，有一些是核蛋白。据报道，其中几种核蛋白，如p53、Nur77、组蛋白H1.2和核磷蛋白，会在细胞质和/或线粒体中积累，并在凋亡应激源的作用下促进线粒体凋亡途径。在这篇综述中，我们将讨论这些及其他核蛋白在促进线粒体凋亡途径中的功能、调节它们在细胞质和/或线粒体中积累的机制，以及Bax和Bak在这一过程中的潜在作用。本文是名为“线粒体：致命细胞器”的特刊的一部分。
