Munksgaard E C
Department of Dental Materials & Technology, Royal Dental College, Copenhagen N, Denmark.
J Dent Res. 1990 Jun;69(6):1236-9. doi: 10.1177/00220345900690060201.
Aqueous mixtures of HEMA with glutaraldehyde or propionaldehyde polymerize by addition of catalytic amounts of amines or amino acids. The maximal reaction velocity of the transformation of HEMA/glutaraldehyde with glycine was obtained at pH 0.8. Kinetic data suggested a second-order reaction between glutaraldehyde and glycine, and solubility data suggested formation of a cross-linked polymer. A relatively high bond strength between dentin and resin composite was obtained by pre-treatment of dentin with Gluma (35% HEMA, 5% glutaraldehyde in water) adjusted to pH 1.0 with hydrochloric acid. It is proposed that on application of Gluma, amino-group-containing substances in dentin react with glutaraldehyde and start the formation of a HEMA polymer. This product may be cross-linked by an alpha,beta-unsaturated glutaraldehyde aldol condensation product and may bond to dentin by aldehyde fixation to dentin proteins. Resin composite will bond to this product by copolymerization.
甲基丙烯酸羟乙酯（HEMA）与戊二醛或丙醛的水性混合物通过添加催化量的胺或氨基酸进行聚合反应。在pH值为0.8时，HEMA/戊二醛与甘氨酸反应的最大反应速度得以实现。动力学数据表明戊二醛与甘氨酸之间发生二级反应，溶解度数据表明形成了交联聚合物。用盐酸将Gluma（35% HEMA，5%戊二醛水溶液）调节至pH值1.0，用其预处理牙本质后，牙本质与树脂复合材料之间可获得相对较高的粘结强度。有人提出，应用Gluma时，牙本质中含氨基的物质会与戊二醛发生反应，从而启动HEMA聚合物的形成。该产物可能会通过α,β-不饱和戊二醛醛醇缩合产物发生交联，并可能通过醛基固定在牙本质蛋白上而与牙本质结合。树脂复合材料将通过共聚作用与该产物结合。
