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西班牙一位硬性透气性角膜接触镜佩戴者因基因型 T11 感染棘阿米巴角膜炎。

Acanthamoeba keratitis due to genotype T11 in a rigid gas permeable contact lens wearer in Spain.

机构信息

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain.

出版信息

Cont Lens Anterior Eye. 2011 Apr;34(2):83-6. doi: 10.1016/j.clae.2010.10.007. Epub 2010 Dec 3.

Abstract

A case of a 59-year-old Spanish patient who presented with severe ocular pain, blurred vision, eyelid swelling and foreign body sensation in the right eye is reported. She was a regular gas permeable contact lens [corrected] wearer who initially claimed to maintain standard lens care. After exploration, conjunctival injection, dendritiform corneal ulcers and stromal edema were observed. She was initially treated for a possible viral keratitis due to herpes simplex virus using 3% topical acyclovir and 0.1% dexamethasone eye drops 5 times a day. The patient did not respond to this treatment and six weeks later, corneal scrapings were positive for Acanthamoeba genotype T11. She was then treated with chlorhexidine 0.02%, propamidine 0.1% and 1% cycloplegic eye drops hourly which resulted in a significant improvement. After a month, ocular pain decreased and the clinical signs of keratitis ameliorated observed as a diminution of the size of the ulcer and also in the extension and opacity of the corneal infiltrates. The patient has been following this treatment for 3 months and it is possible that she will have to carry on with it for a whole year. To the best of our knowledge, this is the first case of severe keratitis due to Acanthamoeba genotype T11 in Spain .

摘要

现报道一例 59 岁西班牙女性患者,其右眼出现严重眼痛、视力模糊、眼睑肿胀和异物感。她是一位经常佩戴透气性角膜接触镜的患者,最初声称遵循标准的镜片护理。经检查,发现结膜充血、树枝状角膜溃疡和基质水肿。由于疑似单纯疱疹病毒引起的病毒性角膜炎,她最初接受了 3%阿昔洛韦滴眼液和 0.1%地塞米松滴眼液 5 次/天的治疗。但患者对此治疗反应不佳,六周后,角膜刮片显示棘阿米巴属 T11 基因型阳性。随后,她接受了 0.02%洗必泰、0.1%丙脒和 1%散瞳滴眼液每小时滴眼治疗,病情显著改善。一个月后,眼部疼痛减轻,角膜炎的临床体征改善,溃疡的大小以及角膜浸润的范围和混浊度均有所缩小。患者已接受该治疗 3 个月,可能需要继续治疗一年。据我们所知,这是西班牙首例由棘阿米巴属 T11 基因型引起的严重角膜炎病例。

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