可溶性 TWEAK 血浆水平可预测人类腹主动脉瘤的扩张。
Soluble TWEAK plasma levels predict expansion of human abdominal aortic aneurysms.
机构信息
Vascular Research Lab, IIS-Fundación Jiménez Díaz, Autónoma University, Av Reyes Católicos 2, 28040 Madrid, Spain.
出版信息
Atherosclerosis. 2011 Feb;214(2):486-9. doi: 10.1016/j.atherosclerosis.2010.11.009. Epub 2010 Nov 12.
OBJECTIVES
Diminished soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) concentrations are associated with cardiovascular diseases. We have analyzed sTWEAK levels and its relation with expansion rate in subjects with abdominal aortic aneurysm (AAA).
METHODS
sTWEAK levels were measured by ELISA.
RESULTS
sTWEAK concentrations were diminished in small AAA (≤ 5 cm; 353 ± 12 pg/mL; n = 25, p = 0.03) and large AAA (>5 cm; 315 ± 21 pg/mL; n = 18, p = 0.004) compared with healthy subjects (411 ± 22 pg/mL; n=27). Moreover, sTWEAK concentrations were negatively associated with AAA size (r = -0.4; p = 0.008). sTWEAK was also negatively associated with AAA expansion rate with 5 years of follow-up (n = 79, r = -0.263; p = 0.031). Multivariate regression analysis revealed that sTWEAK levels were independently associated with AAA growth rate (β = -0.208; p = 0.046).
CONCLUSIONS
sTWEAK plasma levels were decreased in subjects with AAA and were independently related with AAA expansion rate indicating that this protein could be a novel diagnostic and prognostic biomarker of AAA.
目的
可溶性肿瘤坏死因子样弱凋亡诱导剂（sTWEAK）浓度降低与心血管疾病有关。我们分析了腹主动脉瘤（AAA）患者的 sTWEAK 水平及其与扩张率的关系。
方法
通过 ELISA 测定 sTWEAK 水平。
结果
与健康受试者（n=27，411±22pg/ml）相比，小 AAA（≤5cm；n=25，353±12pg/ml，p=0.03）和大 AAA（>5cm；n=18，315±21pg/ml，p=0.004）的 sTWEAK 浓度降低。此外，sTWEAK 浓度与 AAA 大小呈负相关（r=-0.4；p=0.008）。sTWEAK 与 5 年随访期间的 AAA 扩张率也呈负相关（n=79，r=-0.263；p=0.031）。多变量回归分析显示，sTWEAK 水平与 AAA 生长率独立相关（β=-0.208；p=0.046）。
结论
AAA 患者的 sTWEAK 血浆水平降低，与 AAA 扩张率独立相关，表明该蛋白可能是 AAA 的一种新的诊断和预后生物标志物。
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