Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing 100730, China.
Department of Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Exp Biol Med (Maywood). 2021 May;246(9):1054-1059. doi: 10.1177/1535370221992530. Epub 2021 Feb 27.
As a prevalent potentially life-threatening condition, abdominal aortic aneurysm (AAA) presents increasing risk of rupture as its diameter grows. However, rapid progression and rupture may occasionally occur in smaller AAAs. Earlier surgery for patients with high risk of disease progression may improve the outcome. Therefore, more precise indicators for invasive treatment in addition to diameter and abdominal symptoms are demanded. This systematic review aimed to identify potential circulating biomarkers that may predict growth rate of AAA. Cochrane and PubMed library were searched (until August 2020) for researches which reported circulating biomarkers associated with AAA expansion, and 25 papers were included. Twenty-eight identified biomarkers were further classified into five categories (inflammation and oxidative stress, matrix degradation, hematology and lipid metabolism, thrombosis and fibrinolysis, and others), and discussed further with their correlation and regression analysis results. Larger prospective trials are required to establish and evaluate prognostic models with highest values with these markers.
作为一种普遍存在的潜在危及生命的疾病，腹主动脉瘤（AAA）随着其直径的增大，破裂的风险不断增加。然而，较小的 AAA 有时也会迅速进展并破裂。对于疾病进展风险较高的患者，早期手术可能会改善预后。因此，除了直径和腹部症状外，还需要更精确的侵入性治疗指标。本系统评价旨在确定可能预测 AAA 生长速度的潜在循环生物标志物。检索了 Cochrane 和 PubMed 图书馆（截至 2020 年 8 月）中与 AAA 扩张相关的研究报告，并纳入了 25 篇论文。进一步将 28 种已确定的生物标志物分为五类（炎症和氧化应激、基质降解、血液学和脂质代谢、血栓形成和纤维蛋白溶解以及其他），并结合它们的相关性和回归分析结果进行了进一步讨论。需要更大规模的前瞻性试验来建立和评估这些标志物的最高价值的预后模型。
