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持续性失语状态癫痫发作后长时间全身性强直阵挛性发作与 Todd 麻痹的特殊特征。

Recurrent aphasic status epilepticus after prolonged generalized tonic-clonic seizures versus a special feature of Todd's paralysis.

机构信息

Klinik und Poliklinik für Neurologie, Universität Rostock, Rostock, Germany.

出版信息

Epilepsy Behav. 2011 Jan;20(1):132-7. doi: 10.1016/j.yebeh.2010.11.001. Epub 2010 Dec 4.

Abstract

Postictal aphasia may be a feature of Todd's paralysis or the presentation of aphasic nonconvulsive status epilepticus (NCSE). We describe a 74-year-old woman with three episodes of aphasic status epilepticus after prolonged generalized tonic-clonic seizures. In the first episode, the NCSE was not definitively diagnosed, but an increase in the epileptic medication led to resolution of the epileptic activity within 2 weeks. During the second episode, NCSE was terminated within 7 days under intensified antiepileptic treatment. In the third episode, phenytoin treatment led to intoxication and resulted in further treatment on an intensive care unit. The patient required several months to recover from this episode. NCSE in the elderly is difficult to recognize, especially when it presents as a prolonged postictal deficit like aphasia. Once diagnosed it has to be treated carefully, because in the elderly, aggressive treatment strategies may be associated with a high risk of adverse events.

摘要

发作后失语症可能是 Todd 麻痹的特征,也可能是失语性非惊厥性癫痫持续状态(NCSE)的表现。我们描述了一位 74 岁女性,在长时间全身强直阵挛性发作后出现了 3 次失语性癫痫持续状态发作。在第 1 次发作中,未明确诊断为 NCSE,但增加癫痫药物治疗后,癫痫活动在 2 周内得到解决。在第 2 次发作中,在强化抗癫痫治疗下 7 天内终止了 NCSE。在第 3 次发作中,苯妥英钠治疗导致中毒,并导致在重症监护病房进一步治疗。患者需要几个月才能从这一次发作中恢复。老年人的 NCSE 很难识别,特别是当它表现为长时间的发作后缺损,如失语症。一旦确诊,就必须谨慎治疗,因为在老年人中,积极的治疗策略可能与发生不良事件的高风险相关。

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