North Cumbria University Hospitals, Cumberland Infirmary, Newtown Road, Carlisle, Cumbria CA2 7HY, UK.
Postgrad Med J. 2011 Mar;87(1025):199-206. doi: 10.1136/pgmj.2010.108142. Epub 2010 Dec 3.
Advanced age is associated with the finding of abnormalities on neurological and cognitive assessment. This review aims to identify studies that evaluated community samples of patients without a history of neurological disease and attempts to combine these data. While neurological signs were common, they were not universal and should not be considered an inevitable component of ageing. Additionally, they are associated with an increased risk of multiple adverse outcomes including functional decline and death. Therefore they should not be considered benign. Cognitive changes detected in studies that examined healthy older adults were only mild. More pronounced change suggests the development of dementia or mild cognitive impairment (a precursor to dementia). Changes in either neurological or cognitive examination in older adults should be considered abnormal and due to underlying disease. They should be investigated and treated in a similar way to abnormalities detected in younger individuals.
高龄与神经和认知评估异常的发现有关。本综述旨在确定评估无神经病史的社区患者样本的研究,并尝试合并这些数据。虽然神经体征很常见,但它们并非普遍存在,不应被视为衰老的必然组成部分。此外,它们与多种不良结局的风险增加相关,包括功能下降和死亡。因此,它们不应被视为良性。在检查健康老年人的研究中检测到的认知变化仅为轻度。更明显的变化表明痴呆或轻度认知障碍(痴呆的前兆)的发展。老年人的神经或认知检查的变化应被视为异常,是由潜在疾病引起的。它们应通过类似的方式进行调查和治疗,与在年轻个体中检测到的异常相同。