Bagga P K, Mahajan N C
Department of Pathology, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.
Indian J Cancer. 2010 Oct-Dec;47(4):437-42. doi: 10.4103/0019-509X.73564.
Fine needle aspiration cytology (FNAC) is widely considered as the diagnostic technique of choice in the assessment of thyroid lesions.
The aim of this study is to determine the utility and diagnostic accuracy of FNAC of thyroid lesions performed at our institution and to compare our experience with that of the experts from other regions of the world.
The present study is a five-year retrospective study of FNAC of thyroid lesions performed in the Pathology Department of our institute, during the period January 2004 to December 2008. The FNAC findings were correlated with the histopathological diagnosis, wherever available.
The records of 252 patients who had undergone FNAC during the study period were retrieved and information about age, sex, FNAC, and Histopathological diagnoses were extracted and the corresponding original slides were reviewed. The cytological results were classified as inadequate, benign, suspicious, and malignant. The histopathology diagnosis was classified as non-neoplastic (benign) and neoplastic (malignant).
A total of 252 FNACs of thyroid lesions were done during the study period. The results of the FNA cytological diagnosis showed that four (1.6%) of the patients had FNAs, which were inadequate for cytological assessment, 228 (90.5%) patients had benign lesions, 17 (6.7%) had lesions that were suspicious for malignancy, and three (1.2%) had malignant neoplasms. The correlation of the FNAC findings with the histopathological diagnosis, showed that our FNAC diagnostic accuracy rate was 96.2%, with a sensitivity of 66%, and specificity of 100%.
The results of our study are comparable with the current published data and demonstrate that FNA cytology is a sensitive, specific and accurate initial diagnostic test for the preoperative evaluation of patients with thyroid swellings in our setting as well. The clinicians should be encouraged to embrace this procedure in the initial management of such patients.
细针穿刺细胞学检查（FNAC）被广泛认为是评估甲状腺病变的首选诊断技术。
本研究的目的是确定在我们机构进行的甲状腺病变FNAC的效用和诊断准确性，并将我们的经验与世界其他地区的专家进行比较。
本研究是对2004年1月至2008年12月期间在我们研究所病理科进行的甲状腺病变FNAC的五年回顾性研究。只要可行，FNAC结果就与组织病理学诊断相关联。
检索研究期间接受FNAC的252例患者的记录，提取有关年龄、性别、FNAC和组织病理学诊断的信息，并复查相应的原始玻片。细胞学结果分为不充分、良性、可疑和恶性。组织病理学诊断分为非肿瘤性（良性）和肿瘤性（恶性）。
研究期间共进行了252例甲状腺病变的FNAC。FNA细胞学诊断结果显示，4例（1.6%）患者的FNA细胞学评估不充分，228例（90.5%）患者有良性病变，17例（6.7%）有可疑恶性病变，3例（1.2%）有恶性肿瘤。FNAC结果与组织病理学诊断的相关性显示，我们的FNAC诊断准确率为96.2%，敏感性为66%，特异性为100%。
我们的研究结果与目前发表的数据相当，表明FNA细胞学也是我们环境中甲状腺肿大患者术前评估的一种敏感、特异和准确的初始诊断测试。应鼓励临床医生在这类患者的初始管理中采用这一程序。
