Department of Medical Oncology, Bellaria Hospital, Via Altura 3, Bologna, Italy.
Nat Rev Neurol. 2010 Dec;6(12):653-4. doi: 10.1038/nrneurol.2010.176.
Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults. Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.
两项新研究表明，小儿髓母细胞瘤和高级别神经胶质瘤在基因上与成人的相同肿瘤不同。年龄相关的基因表达可能会影响肿瘤生物学；因此，成人髓母细胞瘤或神经胶质瘤的治疗方法在儿科患者中可能不会产生相同的临床结果，反之亦然。
