Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Zurich, Switzerland.
Bone Marrow Transplant. 2011 Sep;46(9):1245-55. doi: 10.1038/bmt.2010.288. Epub 2010 Dec 6.
Patients who undergo hematopoietic SCT (HSCT) often experience physical and psychological problems, even long after treatment has been completed. This study was performed to evaluate the effects of a 12-week outpatient physical exercise (PE) program, incorporating aerobic and strength exercises, as compared with a usual care control condition on patients' physical performance and psychosocial well-being. Patients who had completed HSCT up to 6 months earlier were randomly assigned to a supervised PE program (n=64) or a usual care control group (n=67). Primary outcomes were quantified physical performance and self-reported physical functioning. Secondary outcomes were body composition measurement, quantified walking activity and patient-reported outcomes (physical activity, fatigue and health-related quality of life). Assessments were at baseline, immediately after program completion and at 3-month follow-up. Significant intervention effects were observed at both posttreatment and follow-up on physical performance measures. No other outcomes yielded statistically significant group differences. PE should be considered in the management of HSCT recipients to improve physical performance after discharge from the hospital. Further research is needed to determine how the program can be enhanced so that improved physical performance also translates into improved physical and psychosocial functioning in daily life.
接受造血干细胞移植（HSCT）的患者在治疗完成后很长一段时间内经常会出现身体和心理问题。本研究旨在评估为期 12 周的门诊体育锻炼（PE）计划的效果，该计划结合了有氧运动和力量训练，与常规护理对照组相比，对患者的身体表现和心理社会健康的影响。已完成 HSCT 治疗且时间不超过 6 个月的患者被随机分配到监督 PE 计划组（n=64）或常规护理对照组（n=67）。主要结局指标是量化的身体表现和自我报告的身体功能。次要结局指标是身体成分测量、量化的步行活动和患者报告的结果（身体活动、疲劳和健康相关生活质量）。评估在基线、方案完成后即刻以及 3 个月随访时进行。在治疗后和随访时，身体表现测量均观察到显著的干预效果。其他结果均未显示出统计学意义上的组间差异。PE 应在 HSCT 受者的管理中考虑，以改善出院后的身体表现。需要进一步研究如何增强该方案，以便改善身体表现也能转化为日常生活中身体和心理社会功能的改善。
