Daoud A S, Zaki M, Shakir R, al-Saleh Q
Department of Paediatrics, Farwania Hospital, Kuwait.
Neurology. 1990 Jul;40(7):1140-1. doi: 10.1212/wnl.40.7.1140.
We treated 15 children with Sydenham's chorea with sodium valproate at a dose of 15 to 20 mg/kg/d. In 13 of them the chorieform movements disappeared within 1 week of therapy. The remaining 2 had incomplete response. Two patients relapsed; 1 of them responded to the reintroduction of valproate. The mean duration of treatment was 6.7 weeks. We observed no major side effects. This study strongly suggests that valproate is an effective drug in the treatment of Sydenham's chorea.
我们用丙戊酸钠以15至20毫克/千克/天的剂量治疗了15名患有 Sydenham 舞蹈病的儿童。其中13名患儿的舞蹈样动作在治疗1周内消失。其余2名患儿反应不完全。2名患者复发；其中1名对重新使用丙戊酸钠有反应。平均治疗持续时间为6.7周。我们未观察到严重副作用。本研究强烈表明丙戊酸钠是治疗 Sydenham 舞蹈病的有效药物。
