The Ecology of Tumors: By perturbing the microenvironment, wounds and infection may be key to tumor development.
作者信息
Kenny Paraic A, Nelson Celeste M, Bissell Mina J
机构信息
Mina Bissell is distinguished scientist, and Paraic Kenny and Celeste Nelson are postdoctoral fellows in the Life Sciences Division of the Lawrence Berkeley National Laboratory.
出版信息
Scientist. 2006 Apr 1;20(4):30.
Abstract
No tumor is an island. Chemical and physical forces exerted by the diverse cellular populations that surround a tumor - its so-called microenvironment - shape development and progression. Manipulating these 'ecological' factors is increasingly attractive therapeutically, as Mina Bissell and colleagues discuss in the following pages. And just as the cellular neighborhood is diverse, tumors enriched in these environments comprise a variety of cell types. In this heterogeneous mix, increasing evidence points to so-called cancer stem cells as the root of malignancy. Irving Weissman and Michael Clarke discuss the implications for leukemias on page 35, and on page 37 Peter B. Dirks discusses cancer stem cells in the brain.
摘要
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本文引用的文献
1
Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.
Cold Spring Harb Symp Quant Biol. 2005;70:343-56. doi: 10.1101/sqb.2005.70.013.
2
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo.
Cancer Res. 2006 Feb 1;66(3):1526-35. doi: 10.1158/0008-5472.CAN-05-3071.
3
Tensional homeostasis and the malignant phenotype.
Cancer Cell. 2005 Sep;8(3):241-54. doi: 10.1016/j.ccr.2005.08.010.
4
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.
Nature. 2005 Jul 7;436(7047):123-7. doi: 10.1038/nature03688.
5
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
Science. 2004 Feb 6;303(5659):848-51. doi: 10.1126/science.1090922.
6
Tumour-educated macrophages promote tumour progression and metastasis.
Nat Rev Cancer. 2004 Jan;4(1):71-8. doi: 10.1038/nrc1256.
7
Tumor reversion: correction of malignant behavior by microenvironmental cues.
Int J Cancer. 2003 Dec 10;107(5):688-95. doi: 10.1002/ijc.11491.
8
Inflammation and cancer.
Nature. 2002;420(6917):860-7. doi: 10.1038/nature01322.
9
Neurofibromas in NF1: Schwann cell origin and role of tumor environment.
Science. 2002 May 3;296(5569):920-2. doi: 10.1126/science.1068452.
10
Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.
Am J Pathol. 1999 Sep;155(3):739-52. doi: 10.1016/S0002-9440(10)65173-5.
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