Lu Zhongqi, Fu Qiang, Sui Jinyuan, Chang Ying, Jin Tiefeng, Zhang Meihua
Department of Ultrasound Medicine, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin, China.
Tumor Research Center of Yanbian University, Yanji 133000, Jilin, China.
J Oncol. 2022 Nov 23;2022:5095176. doi: 10.1155/2022/5095176. eCollection 2022.
Cancer, as the second leading cause of death worldwide, has become an ongoing public health challenge and its treatment has received much attention, with immunotherapy becoming a hot research topic in recent years. The interferon gene stimulating factor (STING)-mediated signaling pathway has a "double-edged sword" role in cancer, which plays different roles in different types and stages of tumors. In this paper, we discuss the current research status, cooperation, and hotspots of STING signaling pathway in cancer from 2008-2022 using CiteSpace software based on the literature of cancer and STING signaling pathway. In addition, we predicted future research trends in this field by analysis, and the results showed that the STING signaling pathway is rapidly increasing in cancer research, and its role in tumor microenvironment and immunotherapy has become a new hot spot in current research and will continue to receive high attention.
癌症作为全球第二大死因，已成为一个持续存在的公共卫生挑战，其治疗受到广泛关注，免疫疗法近年来成为热门研究课题。干扰素基因刺激因子（STING）介导的信号通路在癌症中具有“双刃剑”作用，在不同类型和阶段的肿瘤中发挥不同作用。本文基于癌症与STING信号通路的文献，使用CiteSpace软件探讨了2008 - 2022年STING信号通路在癌症中的研究现状、合作情况及热点。此外，我们通过分析预测了该领域未来的研究趋势，结果表明STING信号通路在癌症研究中的关注度迅速上升，其在肿瘤微环境和免疫治疗中的作用已成为当前研究的新热点，并将持续受到高度关注。
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