现代衰老生物学理论。
Modern Biological Theories of Aging.
作者信息
Jin Kunlin
机构信息
Aging and Disease, 8001 Redwood, Blvd. Novato, California 94945, USA.
出版信息
Aging Dis. 2010 Oct 1;1(2):72-74.
Abstract
Despite recent advances in molecular biology and genetics, the mysteries that control human lifespan are yet to be unraveled. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. These theories may interact with each other in a complex way. By understanding and testing the existing and new aging theories, it may be possible to promote successful aging.
摘要
尽管分子生物学和遗传学领域最近取得了进展，但控制人类寿命的奥秘仍有待揭开。人们提出了许多理论来解释衰老过程，这些理论主要分为两大类：程序性理论和错误理论，但似乎都不尽人意。这些理论可能以复杂的方式相互作用。通过理解和检验现有的及新的衰老理论，或许有可能促进成功老龄化。
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本文引用的文献
1
Aging and neurogenesis, a lesion from Alzheimer's disease.衰老与神经发生，阿尔茨海默病的病灶。
Aging Dis. 2010 Oct;1(2):158-68. Epub 2010 Apr 28.
2
Insulin, IGF-1 and longevity.胰岛素、IGF-1 与长寿。
Aging Dis. 2010 Oct;1(2):147-57. Epub 2010 Aug 26.
3
Old age as a privilege of the "selfish ones".老年是“自私的人”的特权。
Aging Dis. 2010 Oct;1(2):139-46. Epub 2010 Jul 30.
4
Aging and the Mammalian regulatory triumvirate.衰老与哺乳动物调控三重奏。
Aging Dis. 2010 Oct;1(2):105-38. Epub 2010 Sep 10.
5
Dietary restriction and aging in rodents: a current view on its molecular mechanisms.限制饮食与啮齿动物的衰老：对其分子机制的当前认识。
Aging Dis. 2010 Oct;1(2):89-107. Epub 2010 Sep 29.
6
Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR.自由基在衰老中的信号和损伤功能——自由基理论、适应性反应和 TOR。
Aging Dis. 2010 Oct;1(2):75-88. Epub 2010 Jul 12.
7
Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.神经干细胞中的端粒缩短会破坏神经元分化和神经突形成。
J Neurosci. 2009 Nov 18;29(46):14394-407. doi: 10.1523/JNEUROSCI.3836-09.2009.
8
Life and death: metabolic rate, membrane composition, and life span of animals.生与死：动物的代谢率、膜组成与寿命
Physiol Rev. 2007 Oct;87(4):1175-213. doi: 10.1152/physrev.00047.2006.
9
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.葡萄糖限制通过诱导线粒体呼吸和增加氧化应激来延长秀丽隐杆线虫的寿命。
Cell Metab. 2007 Oct;6(4):280-93. doi: 10.1016/j.cmet.2007.08.011.
10
IODIZED SALT A HUNDRED YEARS AGO.一百年前的加碘盐。
Science. 1935 Oct 11;82(2128):350-1. doi: 10.1126/science.82.2128.350-a.
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