阿片系统及其与交感神经系统相互作用在大鼠多囊卵巢综合征模型构建中的作用。
The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat.
机构信息
Vali-e-Asr, Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Arch Gynecol Obstet. 2011 Apr;283(4):885-92. doi: 10.1007/s00404-010-1776-7. Epub 2010 Dec 4.
BACKGROUND
This study was conducted to evaluate the effect of interaction of sympathetic and opioid systems in the processing of polycystic ovary syndrome modeling in rat.
METHODS
Ninety adult female rats (7-8 weeks of age) were treated with EV for 60 days for induction of follicular cysts (PCO modeling). Clonidine and yohimbine were used for sympathic agonist and antagonist and nalterxone was used for opioid system inhibition. Interactions of two systems were studied.
RESULTS
Our results indicate that both systems and interaction of two systems are effective in processing modeling of PCOS in rat. Interaction of two system drugs decreased estradiol (P < 0.05). Qualitative analysis showed that the bulk of cysts and corpus lutea and dominant follicles were increased in PCO rats in comparison with control group.
CONCLUSION
Therefore there could been an alternative in the treatment of the polycystic ovary syndrome in the rat by using adrenergic agonist and antagonists in combination with naltrexone.
背景
本研究旨在评估交感和阿片系统相互作用在大鼠多囊卵巢综合征模型中的作用。
方法
90 只成年雌性大鼠（7-8 周龄）接受 EV 治疗 60 天以诱导卵泡囊肿（PCO 建模）。可乐定和育亨宾用于交感神经激动剂和拮抗剂，纳曲酮用于阿片系统抑制。研究了两个系统的相互作用。
结果
我们的结果表明，两个系统及其相互作用都能有效处理大鼠的 PCOS 模型。两种系统药物的相互作用降低了雌二醇（P<0.05）。定性分析表明，与对照组相比，PCO 大鼠的囊肿、黄体和优势卵泡数量增加。
结论
因此，通过使用肾上腺素能激动剂和拮抗剂与纳曲酮联合治疗，可能为大鼠多囊卵巢综合征的治疗提供一种替代方法。
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