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理解健康科学中的机制。

Understanding mechanisms in the health sciences.

机构信息

Department of Philosophy, University of Bologna, Via Zamboni 38, 40126 Bologna, Italy.

出版信息

Theor Med Bioeth. 2011 Feb;32(1):5-17. doi: 10.1007/s11017-010-9166-5.

DOI:10.1007/s11017-010-9166-5
PMID:21132564
Abstract

This article focuses on the assessment of mechanistic relations with specific attention to medicine, where mechanistic models are widely employed. I first survey recent contributions in the philosophical literature on mechanistic causation, and then take issue with Federica Russo and Jon Williamson's thesis that two types of evidence, probabilistic and mechanistic, are at stake in the health sciences. I argue instead that a distinction should be drawn between previously acquired knowledge of mechanisms and yet-to-be-discovered knowledge of mechanisms and that both probabilistic evidence and manipulation are essential with respect to newly discovered mechanisms.

摘要

本文重点关注机械关系的评估,特别关注医学领域中广泛应用机械模型的情况。我首先调查了哲学文献中关于机械因果关系的最新贡献,然后对 Federica Russo 和 Jon Williamson 的论点提出质疑,即概率证据和机械证据在健康科学中都有涉及。我认为,应该区分已经获得的机制知识和尚未发现的机制知识,并且对于新发现的机制来说,概率证据和操纵都是必不可少的。

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本文引用的文献

1
Explanation: a mechanist alternative.解释:一种机械论的替代方案。
Stud Hist Philos Biol Biomed Sci. 2005 Jun;36(2):421-41. doi: 10.1016/j.shpsc.2005.03.010.
2
Causal (mis)understanding and the search for scientific explanations: a case study from the history of medicine.因果(错误)理解与科学解释的探寻:医学史上的一个案例研究
Stud Hist Philos Biol Biomed Sci. 2008 Mar;39(1):14-24. doi: 10.1016/j.shpsc.2007.12.016. Epub 2008 Feb 13.
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Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries.
J Biomed Semantics. 2012 Sep 21;3 Suppl 2(Suppl 2):S9. doi: 10.1186/2041-1480-3-S2-S9.
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Causation and melanoma classification.因果关系与黑素瘤分类。
Theor Med Bioeth. 2011 Feb;32(1):19-32. doi: 10.1007/s11017-010-9168-3.
5
Research traditions and evolutionary explanations in medicine.医学中的研究传统和进化解释。
Theor Med Bioeth. 2011 Feb;32(1):75-90. doi: 10.1007/s11017-010-9167-4.
工作组报告:发展中国家减少黄曲霉毒素暴露的公共卫生策略
Environ Health Perspect. 2006 Dec;114(12):1898-903. doi: 10.1289/ehp.9302.
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Molecular pathogenesis of hepatocellular carcinoma.肝细胞癌的分子发病机制
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Peripartum cardiomyopathy.围产期心肌病
Lancet. 2006 Aug 19;368(9536):687-93. doi: 10.1016/S0140-6736(06)69253-2.
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Clinical practice. Paget's disease of bone.临床实践。骨佩吉特病
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Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.不孕症、不孕症治疗与先天性畸形:丹麦国家出生队列研究
BMJ. 2006 Sep 30;333(7570):679. doi: 10.1136/bmj.38919.495718.AE. Epub 2006 Aug 7.
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Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions.发展中国家的人类黄曲霉毒素中毒:毒理学、暴露、潜在健康后果及干预措施综述
Am J Clin Nutr. 2004 Nov;80(5):1106-22. doi: 10.1093/ajcn/80.5.1106.
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An update on the molecular genetics of hepatocellular carcinoma.肝细胞癌分子遗传学的最新进展。
Semin Liver Dis. 2004 Feb;24(1):77-88. doi: 10.1055/s-2004-823102.
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THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION?环境与疾病:关联还是因果关系?
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