化疗和放疗引起的口腔黏膜炎：病理生物学、流行病学与管理

Chemotherapy- and radiotherapy-induced oral mucositis: pathobiology, epidemiology and management.

作者信息

Feller L, Essop R, Wood N H, Khammissa R A G, Chikte U M E, Meyerov R, Lemmer J

机构信息

Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa.

出版信息

SADJ. 2010 Sep;65(8):372-4.

PMID:21133051

Abstract

Oral mucositis is a debilitating complication of anticancer treatment, characterised by erythematous, atrophic, erosive or ulcerative lesions. Oral mucositis is almost always painful, affects eating, sleeping, and speech and affects the physiological and social well-being of the patient. The pathophysiology of the condition is not well understood. Guidelines to the treatment of oral mucositis are often contradictory so that there is no evidence based standard treatment protocol. Therefore the treatment is empiric. This paper offers a brief review of current knowledge of the pathophysiology and treatment of oral mucositis.

摘要

口腔黏膜炎是抗癌治疗中一种使人衰弱的并发症，其特征为红斑、萎缩、糜烂或溃疡性病变。口腔黏膜炎几乎总是疼痛的，会影响进食、睡眠和言语，进而影响患者的生理和社会福祉。该病症的病理生理学尚未完全明确。口腔黏膜炎的治疗指南常常相互矛盾，因此不存在基于证据的标准治疗方案。所以治疗是经验性的。本文简要综述了目前关于口腔黏膜炎病理生理学和治疗的知识。