Pereira Igor Figueiredo, Firmino Ramon Targino, Meira Henrique Cortes, DO Egito Vasconcelos Belmiro Cavalcanti, DE Souza Noronha Vladimir Reimar Augusto, Santos Vagner Rodrigues
Department of Prosthodontics and Bucco-Facial Surgery, School of Dentistry, University of Pernambuco, Camaragibe, Brazil
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil.
In Vivo. 2019 Mar-Apr;33(2):605-609. doi: 10.21873/invivo.11517.
Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors.
A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)].
Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06).
Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.
目的：确定放射性口腔黏膜炎（OM）的患病率及相关因素。
在一家参考牙科护理中心进行了一项横断面回顾性研究。使用接受头颈部癌放射治疗患者的病历收集临床和人口统计学变量。数据进行描述性分析和具有稳健方差的多变量泊松回归分析[p<0.05；95%置信区间（CI）]。
分析了413例患者。平均年龄为55±14岁。总体样本中OM的患病率为41.9%，男性患病率更高（78.2%）。以下变量与结果显著相关：放射剂量[患病率比（PR）=1.04；95%CI=1.02 - 1.06]；同步化疗（PR=1.48，95%CI=1.05 - 2.08）；口腔念珠菌病（PR=1.97，95%CI=1.44 - 2.68）；以及放射性骨坏死（PR=1.51，95%CI=1.10 - 2.06）。
放射性OM与放射剂量、同步化疗、口腔念珠菌病和放射性骨坏死相关。OM的发生率强调了头颈部癌治疗前充分口腔护理的重要性。
