Manchanda Parmeet Kaur, Konwar Rituraj, Nayak V Lakshma, Singh Vishwajeet, Bid Hemant Kumar
Division of Endocrinology, James Cancer Center, The Ohio State University, Columbus, OH, USA.
Asian Pac J Cancer Prev. 2010;11(4):1005-8.
Several genetic studies worldwide have recommended VDR as a candidate gene for determining risk of benign prostate hyperplasia (BPH). We investigated the association between VDR gene polymorphisms and the risk of BPH in an Indian male population. Three polymorphic sites of VDR gene, viz., Fok-I, Taq-I and Bsm-I were genotyped in 160 BPH patients and 160 controls. Logistic regression models were used to determine the genetic effects using SPSS statistical software. A statistically significant association between VDR genotype (Taq-I and Bsm-I) and BPH (p=0.02 and 0.03) was obtained. In exploratory analyses, we also examined the association with responder and non-responder subgroups of patients for association of VDR (Taq-I) genotype with drug responsiveness. Our results established that Taq-I and Bsm-I genetic variants of VDR gene influence susceptibility BPH in Indian population. VDR genotypes specifically, Taq-I polymorphic variant is significantly associated with the improvement of BPH patients with standard drug therapy.
全球多项基因研究推荐维生素D受体（VDR）作为决定良性前列腺增生（BPH）风险的候选基因。我们在印度男性人群中研究了VDR基因多态性与BPH风险之间的关联。对160例BPH患者和160例对照进行了VDR基因的三个多态性位点，即Fok - I、Taq - I和Bsm - I的基因分型。使用SPSS统计软件通过逻辑回归模型确定遗传效应。获得了VDR基因型（Taq - I和Bsm - I）与BPH之间具有统计学意义的关联（p = 0.02和0.03）。在探索性分析中，我们还检查了VDR（Taq - I）基因型与药物反应性在患者反应者和无反应者亚组中的关联。我们的结果表明，VDR基因的Taq - I和Bsm - I基因变异影响印度人群中BPH的易感性。具体而言，VDR基因型Taq - I多态性变异与标准药物治疗的BPH患者病情改善显著相关。
