Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Metab Syndr Relat Disord. 2011 Apr;9(2):119-25. doi: 10.1089/met.2010.0079. Epub 2010 Dec 6.
Carotid artery intima-media thickness (IMT) is greater in adults with elevated metabolic risk profiles. However, the influence of body mass index (BMI) or waist circumference (WC) on the relationship between IMT and metabolic risk is unclear.
Adults from the Bogalusa Heart Study were classified as normal weight, overweight, or obese and into WC categories (men, low <94 cm, moderate 94-101.9 cm, high ≥102 cm; women, low <80 cm, moderate 80-87.9 cm, high ≥88 cm). Elevated metabolic risk was defined by cardiovascular risk factor clustering (≥2 abnormal risk factors or insulin resistance (upper quartile of homeostasis model of insulin resistance). Carotid ultrasound measurements were obtained and mean IMT was calculated. General linear models compared IMT between elevated versus normal metabolic risk groups, adjusting for sex, age, race/ethnicity, and either BMI or WC category.
Adults were 24-43 years of age (n = 991) and 41% had elevated metabolic risk (42% male, 28% African American, 38% obese). IMT (mm) was greater in adults with elevated metabolic risk (0.83 ± 0.007) versus normal risk (0.80 ± 0.006) whether adjusted by BMI or WC (both P < 0.0005). IMT was greater in adults with elevated compared to normal metabolic risk within normal-weight (0.84 ± 0.016 vs. 0.79 ± 0.008; P = 0.002), and obese adults (0.86 ± 0.009 vs. 0.80 ± 0.01; P = 0.03), but not significantly different between risk groups in overweight adults. Similar results were found when stratified by WC category.
Adults with elevated metabolic risk have greater IMT than those with normal risk in normal-weight, overweight, low WC, and high WC, but not significant for overweight or moderate WC categories.
颈动脉内膜中层厚度（IMT）在代谢风险升高的成年人中更大。然而，BMI 或腰围（WC）对 IMT 与代谢风险之间关系的影响尚不清楚。
博加拉卢萨心脏研究中的成年人被分为正常体重、超重或肥胖，并分为 WC 类别（男性，低<94cm，中 94-101.9cm，高≥102cm；女性，低<80cm，中 80-87.9cm，高≥88cm）。代谢风险升高的定义为心血管危险因素聚集（≥2 个异常危险因素或胰岛素抵抗（胰岛素抵抗稳态模型的上四分位数）。进行颈动脉超声测量并计算平均 IMT。一般线性模型比较了代谢风险升高与正常组之间的 IMT，调整了性别、年龄、种族/民族以及 BMI 或 WC 类别。
成年人年龄为 24-43 岁（n=991），41%的人代谢风险升高（42%为男性，28%为非裔美国人，38%为肥胖）。无论通过 BMI 还是 WC 调整（均 P<0.0005），代谢风险升高的成年人 IMT（mm）大于代谢风险正常的成年人（0.83±0.007 对 0.80±0.006）。与代谢风险正常的成年人相比，正常体重（0.84±0.016 对 0.79±0.008；P=0.002）和肥胖成年人（0.86±0.009 对 0.80±0.01；P=0.03）中代谢风险升高的成年人 IMT 更大，但在超重成年人中两组之间无显著差异。按 WC 类别分层时也得到了类似的结果。
与代谢风险正常的成年人相比，无论体重指数或腰围是否正常、超重或处于 WC 中度范围，代谢风险升高的成年人 IMT 更大，但在超重或 WC 中度范围时无显著差异。
