Department of Endocrinology and Metabolism, Affiliated Sixth People’s Hospital of Shanghai Jiaotong University; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai 200233, China.
Biomed Environ Sci. 2013 Jul;26(7):531-8. doi: 10.3967/0895-3988.2013.07.003.
To evaluate whether waist circumference (WC) ≥85 cm is related to asymptomatic preclinical atherosclerosis in women from Shanghai, China.
A total of 2365 females aged ≥20 years recruited from 4 communities underwent physical examination and carotid artery scanning. Their carotid intima-media thickness (C-IMT) was measured.
The C-IMT was significantly higher in overweight or obese women with their BMI ≥25.0 kg/m2(P<0.01) and in those with their WC ≥85 cm than in those with their WC <85 cm (P<0.01). Spearman and partial correlation analysis showed that the C-IMT was significantly correlated with WC which was independent of menopausal status. The C-IMT significantly increased with the increasing WC and reached to a platform in about 85 cm. An increment tendency was found in the subgroup with its WC <85 cm (P<0.01) while no significant tendency was found in the subgroup with its WC≥85 cm (P=0.07).Multiple stepwise regression analysis showed that the WC was an independent risk factor for C-IMT. In logistic regression model, the odd ratio of WC ≥80 cm, ≥80 cm and <85 cm and ≥85 cm for evaluating the risk of C-IMT elevation was 1.632, 1.501, and 1.878, respectively.
WC is significantly correlated with C-IMT in women from Shanghai, China, and WC≥85 cm may be used in identifying the risk of subclinical carotid atherosclerosis.
评估中国上海女性的腰围（WC）≥85cm 是否与无症状的亚临床动脉粥样硬化有关。
共纳入 2365 名年龄≥20 岁的女性，来自 4 个社区，进行体格检查和颈动脉扫描。测量她们的颈动脉内膜中层厚度（C-IMT）。
超重或肥胖且 BMI≥25.0kg/m2 的女性（P<0.01）和 WC≥85cm 的女性的 C-IMT 明显高于 WC<85cm 的女性（P<0.01）。Spearman 和偏相关分析表明，C-IMT 与 WC 显著相关，且与绝经状态无关。C-IMT 随着 WC 的增加而显著增加，在大约 85cm 处达到平台。在 WC<85cm 的亚组中，发现了递增趋势（P<0.01），而在 WC≥85cm 的亚组中则没有明显的递增趋势（P=0.07）。多元逐步回归分析表明，WC 是 C-IMT 的独立危险因素。在逻辑回归模型中，WC≥80cm、≥80cm 和<85cm 以及 WC≥85cm 评估 C-IMT 升高风险的比值比分别为 1.632、1.501 和 1.878。
在中国上海女性中，WC 与 C-IMT 显著相关，WC≥85cm 可用于识别亚临床颈动脉粥样硬化的风险。
