Department of Plastic Surgery, Diabetic Wound Center, Korea University Guro Hospital, Seoul, South Korea.
Wound Repair Regen. 2011 Jan-Feb;19(1):19-24. doi: 10.1111/j.1524-475X.2010.00641.x. Epub 2010 Dec 6.
Percutaneous transluminal angioplasty (PTA) has been performed as an alternative to bypass surgery for improving tissue oxygenation in ischemic diabetic feet because the former is less invasive than the latter. The purpose of this study was to evaluate the effect of PTA on tissue oxygenation in ischemic diabetic feet. This study included 29 ischemic diabetic feet, as determined by a transcutaneous oxygen pressure (TcPO(2) )<30 mmHg. The PTA was carried out in 29 limbs. The PTA procedure was considered successful, acceptable, and failed when residual stenosis was<30%, between 30 and 50%, and>50%, respectively. For evaluation of tissue oxygenation, the foot TcPO(2) was measured before PTA and weekly for 6 weeks after PTA. Immediately after PTA, 26 feet were evaluated as being successful and the remaining three as acceptable. Before PTA, the average foot TcPO(2) was 12.7 ± 8.9 mmHg. The TcPO(2) values were increased to 43.6 ± 24.1, 51.0 ± 22.6, 58.3 ± 23.0, 61.3 ± 24.2, 59.0 ± 22.2, and 53.8 ± 21.0 mmHg 1, 2, 3, 4, 5, and 6 weeks after PTA, respectively (p<0.01). The PTA procedure significantly increases tissue oxygenation in ischemic diabetic feet. The maximal level of tissue oxygenation was measured on the fourth week following PTA.
经皮腔内血管成形术（PTA）已被作为改善缺血性糖尿病足组织氧合的一种替代旁路手术，因为前者比后者的侵入性更小。本研究的目的是评估 PTA 对缺血性糖尿病足组织氧合的影响。本研究包括 29 例经皮氧分压（TcPO（2））<30mmHg 的缺血性糖尿病足。对 29 条肢体进行了 PTA。当残余狭窄<30%、30%-50%和>50%时，PTA 程序分别被认为是成功的、可接受的和失败的。为了评估组织氧合，在 PTA 前和 PTA 后每周测量足部 TcPO（2），共 6 周。PTA 后立即评估 26 只脚为成功，其余 3 只为可接受。PTA 前，平均足部 TcPO（2）为 12.7±8.9mmHg。TcPO（2）值分别增加到 43.6±24.1、51.0±22.6、58.3±23.0、61.3±24.2、59.0±22.2 和 53.8±21.0mmHg，在 PTA 后 1、2、3、4、5 和 6 周（p<0.01）。PTA 程序显著增加缺血性糖尿病足的组织氧合。在 PTA 后第 4 周测量到最大的组织氧合水平。
