Imperial Vascular Unit, 4615Imperial College NHS Healthcare Trust, Paddington, London, UK.
Angiology. 2021 Mar;72(3):210-220. doi: 10.1177/0003319720969543. Epub 2020 Nov 4.
Peripheral arterial disease (PAD) is associated with reduced lower limb blood flow and tissue perfusion. The consequent reduction in vessel wall shear stress as well as ischemia-reperfusion injury has also been associated with systemic endothelial dysfunction and inflammation. We aimed to explore the impact of lower limb revascularization on (1) lower limb blood flow, (2) tissue perfusion, and (3) systemic endothelial function. We performed a systematic literature search using the MEDLINE, Embase, and Web of Science databases. Eligible studies measured changes in lower limb blood flow, perfusion, or systemic endothelial function following revascularization for the treatment of symptomatic PAD. We found 19 eligible studies, which were limited by considerable heterogeneity. Current evidence suggests that revascularization has a positive effect on flow, perfusion, and systemic endothelial dysfunction. Any changes may take a number of weeks to become apparent. There is a need for well-designed studies to explore the association between flow, perfusion, and endothelial dysfunction.
外周动脉疾病（PAD）与下肢血流和组织灌注减少有关。随之而来的血管壁切应力降低以及缺血再灌注损伤也与全身内皮功能障碍和炎症有关。我们旨在探讨下肢血运重建对（1）下肢血流、（2）组织灌注和（3）全身内皮功能的影响。我们使用 MEDLINE、Embase 和 Web of Science 数据库进行了系统的文献检索。符合条件的研究测量了下肢血流、灌注或全身内皮功能在治疗有症状的 PAD 的血运重建后发生的变化。我们发现了 19 项符合条件的研究，但这些研究受到相当大的异质性的限制。现有证据表明，血运重建对流量、灌注和全身内皮功能障碍有积极影响。任何变化可能需要数周时间才能显现。需要进行精心设计的研究来探索流量、灌注和内皮功能障碍之间的关系。
