Ishikawa Y, Shimatsu A, Kato Y, Murakami Y, Imura H
Department of Medicine, Kyoto University Faculty of Medicine, Japan.
Brain Res. 1990 Apr 23;514(1):1-4. doi: 10.1016/0006-8993(90)90427-d.
Effects of intrathecal (i.t.) administration of TRH and the TRH analogue, DN1417, on plasma catecholamines and glucose levels were studied in conscious male rats. The i.t. administration of TRH (0.6 and 3 nmol) at the T8-10 vertebral level resulted in a dose-related increase in epinephrine (E), norepinephrine (NE), and glucose levels, which was suppressed by prior administration of the ganglionic blocker, hexamethonium (1.5 mg/100 g b. wt.). I.t. administration of TRH (3 nmol) caused small increases in plasma E and glucose at the C7-T1 vertebral level, but it did not change plasma E, NE and glucose levels at the sacral level. DN1417 (3 nmol) administered i.t. at the T8-10 or C7-T1 vertebral level had a more potent and long-lasting effect in stimulating the release of E than TRH. These findings suggest that TRH may act on sympathetic preganglionic neurons at the T7-10 spinal levels and stimulate the release of catecholamines from the adrenal medulla.
在清醒雄性大鼠中研究了鞘内注射促甲状腺激素释放激素（TRH）及其类似物DN1417对血浆儿茶酚胺和葡萄糖水平的影响。在T8 - 10椎体水平鞘内注射TRH（0.6和3 nmol）导致肾上腺素（E）、去甲肾上腺素（NE）和葡萄糖水平呈剂量相关增加，而预先给予神经节阻滞剂六甲铵（1.5 mg/100 g体重）可抑制这种增加。在C7 - T1椎体水平鞘内注射TRH（3 nmol）可使血浆E和葡萄糖略有增加，但在骶部水平未改变血浆E、NE和葡萄糖水平。在T8 - 10或C7 - T1椎体水平鞘内注射DN1417（3 nmol）在刺激E释放方面比TRH具有更强且持久的作用。这些发现表明，TRH可能作用于T7 - 10脊髓水平的交感神经节前神经元，并刺激肾上腺髓质释放儿茶酚胺。
