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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Shinozuka K, Shimoura K, Hattori K

Department of Pharmacology, Shimane Medical University, Izumo, Japan.

Gen Pharmacol. 1997 Feb;28(2):209-14. doi: 10.1016/s0306-3623(96)00219-4.

Thyrotropin-releasing hormone (TRH) and its metabolically stable analog NS-3 (montirelin hydrate; [3R, 6R]-6-methyl-5-oxo-3-thiomorpholinyl carbonyl-L-histidyl-L-prolinamide tetrahydrate) produced dose-dependent increases in blood pressure, heart rate, and the levels of serum noradrenaline and adrenaline in rats. 2. The pressor and tachycardiac effects and increases in serum catecholamine levels caused by NS-3 were longer lasting, but not more potent than those caused by TRH. 3. NS-3 did not change the blood pressure, heart rate, or the serum catecholamine levels in either pithed or hexamethonium-pretreated rats.

促甲状腺激素释放激素（TRH）及其代谢稳定类似物NS-3（水合蒙替瑞林；[3R, 6R]-6-甲基-5-氧代-3-硫代吗啉基羰基-L-组氨酰-L-脯氨酰胺四水合物）可使大鼠血压、心率以及血清去甲肾上腺素和肾上腺素水平呈剂量依赖性升高。2. NS-3引起的升压和心动过速效应以及血清儿茶酚胺水平升高持续时间更长，但不比TRH引起的效应更强。3. NS-3对脊髓切断或六甲铵预处理大鼠的血压、心率或血清儿茶酚胺水平均无影响。

Shinozuka K, Shimoura K, Hattori K

Department of Pharmacology, Shimane Medical University, Izumo, Japan.

Gen Pharmacol. 1997 Feb;28(2):209-14. doi: 10.1016/s0306-3623(96)00219-4.

Thyrotropin-releasing hormone (TRH) and its metabolically stable analog NS-3 (montirelin hydrate; [3R, 6R]-6-methyl-5-oxo-3-thiomorpholinyl carbonyl-L-histidyl-L-prolinamide tetrahydrate) produced dose-dependent increases in blood pressure, heart rate, and the levels of serum noradrenaline and adrenaline in rats. 2. The pressor and tachycardiac effects and increases in serum catecholamine levels caused by NS-3 were longer lasting, but not more potent than those caused by TRH. 3. NS-3 did not change the blood pressure, heart rate, or the serum catecholamine levels in either pithed or hexamethonium-pretreated rats.

促甲状腺激素释放激素（TRH）及其代谢稳定类似物NS-3（水合蒙替瑞林；[3R, 6R]-6-甲基-5-氧代-3-硫代吗啉基羰基-L-组氨酰-L-脯氨酰胺四水合物）可使大鼠血压、心率以及血清去甲肾上腺素和肾上腺素水平呈剂量依赖性升高。2. NS-3引起的升压和心动过速效应以及血清儿茶酚胺水平升高持续时间更长，但不比TRH引起的效应更强。3. NS-3对脊髓切断或六甲铵预处理大鼠的血压、心率或血清儿茶酚胺水平均无影响。