Nutritional Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Br J Nutr. 2011 Jan;105(1):144-56. doi: 10.1017/S0007114510002576. Epub 2010 Dec 7.
The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and included an open discussion focusing on the identification of the concentrations of serum 25-hydroxyvitamin D (25(OH)D) (a marker of vitamin D status) that may be regarded as optimal, and the implications this process may have in the setting of future dietary reference values for vitamin D in the UK. The Forum was in agreement with the fact that it is desirable for all of the population to have a serum 25(OH)D concentration above 25 nmol/l, but it discussed some uncertainty about the strength of evidence for the need to aim for substantially higher concentrations (25(OH)D concentrations>75 nmol/l). Any discussion of 'optimal' concentration of serum 25(OH)D needs to define 'optimal' with care since it is important to consider the normal distribution of requirements and the vitamin D needs for a wide range of outcomes. Current UK reference values concentrate on the requirements of particular subgroups of the population; this differs from the approaches used in other European countries where a wider range of age groups tend to be covered. With the re-emergence of rickets and the public health burden of low vitamin D status being already apparent, there is a need for urgent action from policy makers and risk managers. The Forum highlighted concerns regarding the failure of implementation of existing strategies in the UK for achieving current vitamin D recommendations.
2009 年 7 月 2 日和 3 日,在英国萨里大学举行了维生素 D 排名论坛。该研讨会由一系列背景介绍组成,旨在解决与维生素 D 和健康相关的当前问题和挑战,其中包括一个开放性讨论,重点是确定血清 25-羟维生素 D(25(OH)D)(维生素 D 状况的标志物)的浓度,这些浓度可能被视为最佳浓度,并探讨这一过程对英国未来制定维生素 D 饮食参考值可能产生的影响。论坛一致认为,所有人群的血清 25(OH)D 浓度高于 25 nmol/L 是理想的,但它也讨论了一些关于需要追求更高浓度(25(OH)D 浓度>75 nmol/L)的证据强度的不确定性。任何关于血清 25(OH)D 最佳浓度的讨论都需要谨慎地定义“最佳”,因为重要的是要考虑到需求的正态分布以及广泛的结果所需的维生素 D 需求。当前英国的参考值集中在特定人群亚组的需求上;这与其他欧洲国家的方法不同,后者往往涵盖了更广泛的年龄组。随着佝偻病的重新出现和维生素 D 状态低下对公众健康的负担已经显现,政策制定者和风险管理者需要采取紧急行动。该论坛强调了对英国目前实现维生素 D 建议的现有策略执行失败的担忧。