Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.
Neurobiol Learn Mem. 2011 Feb;95(2):125-33. doi: 10.1016/j.nlm.2010.11.015. Epub 2010 Dec 4.
This Special Issue of Neurobiology of Learning and Memory dedicated to Dr. Richard Thompson to celebrate his 80th birthday and his numerous contributions to the field of learning and memory gave us the opportunity to revisit the hypothesis we proposed more than 25years ago regarding the biochemistry of learning and memory. This review summarizes our early 1980s hypothesis and then describes how it was tested and modified over the years following its introduction. We then discuss the current status of the hypothesis and provide some examples of how it has led to unexpected insights into the memory problems that accompany a broad range of neuropsychiatric disorders.
本期《学习和记忆的神经生物学》特刊是为了庆祝理查德·汤普森博士 80 岁生日以及他在学习和记忆领域的众多贡献而设立的。这让我们有机会重新审视我们在 25 年前提出的关于学习和记忆的生物化学假说。本综述总结了我们在 20 世纪 80 年代初的假说，然后描述了自提出以来多年来的验证和修改情况。接着，我们讨论了该假说的现状，并提供了一些例子来说明它如何导致对广泛的神经精神疾病伴随的记忆问题的意外洞察。
