Michel J-L, Perrin D
Cabinet de Dermatologie, Avenue Résidence v, 14, Place des Grenadiers-quartier-grouchy, 42000 Saint-Étienne, France.
Ann Dermatol Venereol. 2010 Dec;137(12):803-7. doi: 10.1016/j.annder.2010.08.010.
Jessner's lymphocytic infiltration of the skin (LIS) is a chronic, benign T-cell infiltrative disorder, usually manifesting as erythematous papules or plaques on the face, neck and back.
five patients presented LIS with numerous skin lesions on the face and back characteristic of this disease. Histological examination showed a lymphocytic infiltrate in the dermis without any modification of the epidermis. Direct immunofluorescent study was negative in all cases. Response to dermocorticoids proved inconsistent or negative in all patients. An excellent outcome was achieved in all five patients with pulsed dye laser. In one case, further skin lesions appeared at 1 year and responded to the same treatment. Following a single treatment session with 6-8 J/cm(2), three of five patients showed normal skin. Regression occurred in the other two cases after two to three sessions. Pulsed dye laser appeared to be the best treatment for Jessner-Kanof disease for three patients at 4-8 years of follow-up.
only one case of Jessner-Kanof disease treated by pulsed dye laser has been reported. Pulsed dye laser has been used in cutaneous lupus and annular granuloma. Selective photothermolysis allows photocoagulation of dilated vessels.
pulsed dye laser at 595nm could offer a valuable therapeutic alternative, and even a first-line treatment with no side effects.
Jessner皮肤淋巴细胞浸润症(LIS)是一种慢性良性T细胞浸润性疾病,通常表现为面部、颈部和背部的红斑丘疹或斑块。
5例患者患有Jessner皮肤淋巴细胞浸润症,面部和背部有许多该病特征性的皮肤损害。组织学检查显示真皮有淋巴细胞浸润,表皮无任何改变。直接免疫荧光研究在所有病例中均为阴性。所有患者对皮质类固醇的反应不一致或为阴性。5例患者使用脉冲染料激光均取得了良好疗效。1例患者在1年后出现新的皮肤损害,对同样的治疗有反应。5例患者中,3例单次接受6 - 8 J/cm(2)治疗后皮肤恢复正常。另外2例在接受两到三次治疗后皮损消退。在4 - 8年的随访中,脉冲染料激光似乎是治疗Jessner - Kanof病的最佳方法,对3例患者有效。
仅有1例Jessner - Kanof病采用脉冲染料激光治疗的报道。脉冲染料激光已用于皮肤狼疮和环状肉芽肿。选择性光热解可使扩张的血管发生光凝。
595nm脉冲染料激光可提供一种有价值的治疗选择,甚至可作为一线治疗且无副作用。