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铜配合物与 1,10-菲啰啉和氨基酸的合成、晶体结构及对大肠杆菌的作用的微量热研究

Synthesis, crystal structure and action on Escherichia coli by microcalorimetry of copper complexes with 1,10-phenanthroline and amino acid.

机构信息

School of Science, Wuhan University of Technology, Wuhan 430070, PR China.

出版信息

J Inorg Biochem. 2011 Jan;105(1):23-30. doi: 10.1016/j.jinorgbio.2010.09.001. Epub 2010 Sep 29.

Abstract

Copper complexes: [Cu(phen)(L-Ser)(H(2)O)Cl] (1), [Cu(phen)(Gly)(H(2)O)]Cl·3H(2)O (2), [Cu(phen)(L-Ala)(H(2)O)]Cl·H(2)O (3), [Cu(phen)(L-Phe)(H(2)O)]Cl·2.5H(2)O (4), Cu(phen)(2)Cl(2)·6H(2)O (5) (phen=1,10-phenanthroline) were synthesized and characterized. The structure of 1 was characterized by X-ray crystallography and showed in a triclinic system with space group P1, a=6.8953(15) Å, b=10.737(2) Å, c=11.894(3) Å, α=110.395(3)°, β=94.183(4)° and γ=100.540(3)°. The antibacterial activities on Escherichia coli (E. coli) of these five copper complexes and CuCl(2) (6) were investigated by microcalorimetry. By analyzing the obtained metabolic thermogenic data and curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC(50)), and generation time (t(G)) were determined. All these copper complexes could stimulate the growth of the E. coli at their lower concentration. At their higher concentration they all showed antibacterial action. The inhibition on E. coli was 5>1 ≈ 2 ≈ 3 ≈ 4 > 6. And the antibacterial mechanism was discussed preliminarily.

摘要

铜配合物

[Cu(phen)(L-Ser)(H2O)Cl](1)、[Cu(phen)(Gly)(H2O)]Cl·3H2O(2)、[Cu(phen)(L-Ala)(H2O)]Cl·H2O(3)、[Cu(phen)(L-Phe)(H2O)]Cl·2.5H2O(4)、Cu(phen)(2)Cl2·6H2O(5)(phen=1,10-邻菲啰啉)被合成并进行了表征。1 的结构通过 X 射线晶体学进行了表征,属于三斜晶系,空间群 P1,a=6.8953(15) Å,b=10.737(2) Å,c=11.894(3) Å,α=110.395(3)°,β=94.183(4)°和γ=100.540(3)°。通过微量热法研究了这五个铜配合物和 CuCl2(6)对大肠杆菌(E. coli)的抗菌活性。通过分析获得的代谢产热数据和曲线,确定了关键参数,如细菌生长的速率常数(k)、半抑制浓度(IC50)和世代时间(t(G))。所有这些铜配合物在较低浓度下都能刺激大肠杆菌的生长。在较高浓度下,它们都表现出抗菌作用。对 E. coli 的抑制作用为 5>1 ≈ 2 ≈ 3 ≈ 4 > 6。并初步探讨了其抗菌机制。

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