Vušak Darko, Smrečki Neven, Prugovečki Biserka, Đilović Ivica, Kirasić Inka, Žilić Dijana, Muratović Senada, Matković-Čalogović Dubravka
Department of Chemistry, Faculty of Science, University of Zagreb Horvatovac 102a HR-10000 Zagreb Croatia
Laboratory for Magnetic Resonances, Division of Physical Chemistry, Ruđer Bošković Institute Bijenička 54 HR-10000 Zagreb Croatia.
RSC Adv. 2019 Jul 12;9(38):21637-21645. doi: 10.1039/c9ra03693h. eCollection 2019 Jul 11.
Ten new compounds of Co, Ni and Cu with glycinamide (HL = glycinamide): [Co(HO)(HL)]Cl (1a), [Co(HO)(HL)]BrCl (1b), [Co(HO)(HL)]I (1c), [Ni(HO)(HL)]Cl (2a), [Ni(HO)(HL)]BrCl (2b), [Ni(HO)(HL)]I (low and room temperature polymorph, 2c and 2c), [CuCl(HL)] (3a), [CuBrCl(HL)] (3b) and {[Cu(HL)][CuI]} (3c), as well as glycinamide hydroiodide (HLI) and a new polymorph of glycinamide hydrochloride (β-HLCl) were prepared and characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermal analysis (TG/DTA) and ESR spectroscopy. 1a, 1b, 2a and 2b are isostructural, as well as 1c and 2c, while the Cu compounds (3a-c) have entirely different molecular structures. All investigated compounds are mononuclear with exception of the 1D coordination polymer 3c. Compound 3c contains copper ions in the mixed oxidation state Cu(i) and Cu(ii) with interesting magnetic properties. Paramagnetic behaviour was found in 1a, 1b, 3a and 3b. Temperature induced polymorphic transformation was observed in 2c. Compounds 1a and 3a showed moderate antiproliferative activity and selectivity toward the human breast tumor cell line MCF-7.
十种新的钴、镍和铜与甘氨酰胺（HL = 甘氨酰胺）形成的化合物：[Co(HO)(HL)]Cl (1a)、[Co(HO)(HL)]BrCl (1b)、[Co(HO)(HL)]I (1c)、[Ni(HO)(HL)]Cl (2a)、[Ni(HO)(HL)]BrCl (2b)、[Ni(HO)(HL)]I（低温和室温多晶型物，2c 和 2c）、[CuCl(HL)] (3a)、[CuBrCl(HL)] (3b) 和 {[Cu(HL)][CuI]} (3c)，以及氢碘酸甘氨酰胺（HLI）和盐酸甘氨酰胺的一种新多晶型物（β-HLCl）已通过单晶 X 射线衍射、红外光谱、热分析（TG/DTA）和电子自旋共振光谱进行了制备和表征。1a、1b、2a 和 2b 是同构的，1c 和 2c 也是，而铜化合物（3a - c）具有完全不同的分子结构。除了一维配位聚合物 3c 外，所有研究的化合物都是单核的。化合物 3c 含有混合氧化态 Cu(i) 和 Cu(ii) 的铜离子，具有有趣的磁性。在 1a、1b、3a 和 3b 中发现了顺磁行为。在 2c 中观察到温度诱导的多晶型转变。化合物 1a 和 3a 对人乳腺癌细胞系 MCF - 7 表现出适度的抗增殖活性和选择性。
