患者肝移植术后发生急性排斥反应合并新型 H1N1 甲型流感病毒感染
Novel H1N1 influenza A virus infection in a patient with acute rejection after liver transplantation.
机构信息
Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
出版信息
Hepatobiliary Pancreat Dis Int. 2010 Dec;9(6):658-60.
BACKGROUND
The 2009 H1N1 influenza A virus was first identified in April 2009 and rapidly evolved into a pandemic. Recipients of solid-organ transplants have a higher risk for severe infection because of immunosuppression. There are limited reports of 2009 H1N1 influenza in liver transplant recipients, especially in China.
METHODS
We present a case of a 48-year-old male liver transplant recipient with 2009 H1N1 influenza A virus. He received therapy for acute rejection after transplantation and was confirmed with H1N1 virus infection.
RESULTS
The patient was started on oseltamivir (75 mg, orally twice daily) and had a benign hospital course, with defervescence and resolution of symptoms within 72 hours. The follow-up chest radiograph after discharge was normal.
CONCLUSIONS
The 2009 H1N1 influenza in this hospitalized transplant recipient was relatively mild, and prolonged viral shedding was not noted. Oseltamivir can be a valid measure in immunocompromised individuals.
背景
2009 年甲型 H1N1 流感病毒于 2009 年 4 月首次被发现，并迅速演变为大流行。由于免疫抑制，实体器官移植受者发生严重感染的风险更高。有关肝移植受者感染 2009 年甲型 H1N1 流感的报道很少，特别是在中国。
方法
我们报告了一例 48 岁男性肝移植受者感染 2009 年甲型 H1N1 流感病毒的病例。他在移植后接受了急性排斥反应的治疗，并被确诊为 H1N1 病毒感染。
结果
该患者开始接受奥司他韦（75 mg，口服，每日 2 次）治疗，在医院的病程良好，72 小时内退热并症状缓解。出院后随访的胸部 X 线片正常。
结论
该住院移植受者感染的 2009 年甲型 H1N1 流感相对较轻，未出现病毒持续排出。奥司他韦可能是免疫功能低下者的有效治疗措施。
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