Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petach Tiqwa, Israel.
J Heart Lung Transplant. 2010 Sep;29(9):1034-8. doi: 10.1016/j.healun.2010.05.007. Epub 2010 Jun 16.
The year 2009 was notable for the outbreak of a novel strain of influenza A (H1N1). We report the outcomes of H1N1 infection in a large cohort of lung transplant (LTx) recipients and candidates.
This was a retrospective review of 22 suspected cases of H1N1 influenza screened using real-time polymerase chain reaction from nasal secretions. There were 15 confirmed cases (10 LTx recipients, 5 LTx candidates).
All patients were treated with oseltamivir at the time of the first clinical assessment. In the LTx recipients group, 7 of the 10 confirmed cases were treated at home with oseltamivir alone. Three patients were admitted with complications (2 pneumonia, 1 acute rejection). Two patients required mechanical ventilation. Two patients had prolonged viral shedding. No deaths occurred among the LTx recipients. In the 5 LTx candidates with confirmed H1N1, 2 deaths occurred from pneumonia and acute respiratory distress syndrome.
Influenza H1N1 had a significant complication rate amongst LTx recipients and a high mortality rate amongst LTx candidates.
2009 年，一种新型甲型 H1N1 流感爆发。我们报告了大量肺移植（LTx）受者和候选者中 H1N1 感染的结果。
这是一项回顾性研究，对 22 例疑似甲型 H1N1 流感的患者进行了实时聚合酶链反应检测。确诊病例 15 例（10 例 LTx 受者，5 例 LTx 候选者）。
所有患者在首次临床评估时均接受了奥司他韦治疗。在 LTx 受者组中，10 例确诊病例中有 7 例单独在家接受奥司他韦治疗。3 例患者因并发症入院（2 例肺炎，1 例急性排斥反应）。2 例患者需要机械通气。2 例患者病毒持续排出。LTx 受者中无死亡病例。在 5 例确诊为 H1N1 的 LTx 候选者中，有 2 例因肺炎和急性呼吸窘迫综合征死亡。
流感 H1N1 在 LTx 受者中具有较高的并发症发生率和死亡率，在 LTx 候选者中死亡率较高。
