Departments of Emergency and Critical Care Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Blood Purif. 2011;31(1-3):18-25. doi: 10.1159/000321142. Epub 2010 Dec 7.
BACKGROUND/AIMS: We sought to identify the most relevant hemofilter for cytokine removal based on the mechanisms of filtration and adsorption.
Ascites were filtered using four types of hemofilters composed of different membrane materials (polymethyl methacrylate, PMMA, cellulose triacetate, CTA, or polysulfone, PS) and different surface areas (1.0 or 2.1 m(2)) to investigate the rate of interleukin-6 (IL-6) filtration. Next, ascites were perfused through each hemofilter without obtaining a filtrate to study each filter's adsorptive capability.
The PMMA hemofilters resulted in a marginal observed IL-6 filtration rates, whereas the CTA and PS hemofilters resulted in highly effective IL-6 filtration. Regarding the IL-6 adsorptive capabilities of the filters, the PMMA hemofilter with a large surface area showed the highest level of IL-6 clearance.
The present findings suggest that when cytokine removal based on filtration is desired, CTA or PS hemofilters should be selected. When IL-6 removal based on adsorption is desired, a PMMA hemofilter with a large surface area should be selected.
背景/目的：我们试图根据过滤和吸附的机制，确定最相关的用于细胞因子去除的血液滤过器。
使用由不同膜材料（聚甲基丙烯酸甲酯、PMMA、醋酸纤维素三酯、CTA 或聚砜、PS）和不同表面积（1.0 或 2.1 m²）组成的四种血液滤过器过滤腹水，以研究白细胞介素-6（IL-6）的过滤率。然后，将腹水灌注通过每个血液滤过器而不获得滤液，以研究每个滤器的吸附能力。
PMMA 血液滤过器导致 IL-6 过滤率略有观察到，而 CTA 和 PS 血液滤过器导致高效 IL-6 过滤。关于过滤器的 IL-6 吸附能力，具有大表面积的 PMMA 血液滤过器显示出最高水平的 IL-6 清除率。
本研究结果表明，当基于过滤的细胞因子去除时，应选择 CTA 或 PS 血液滤过器。当基于吸附的 IL-6 去除时，应选择具有大表面积的 PMMA 血液滤过器。
