Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242-1009, USA.
J Clin Gastroenterol. 2011 Sep;45(8):684-90. doi: 10.1097/MCG.0b013e3181ff0122.
To examine the diagnostic utility of wireless motility capsule (WMC) in patients with suspected gastrointestinal (GI) dysmotility.
Subjects with suspected GI motility disorders undergo invasive and expensive diagnostic tests. In these patients, whether WMC provides clinically useful information is unknown.
Patients with symptoms of dysmotility and normal endoscopic/radiologic evaluations were assessed with WMC test and conventional motility tests (CMT). Diagnostic utility of WMC was assessed retrospectively by examining device agreement and new information compared with CMT.
On the basis of predominant symptom(s), 86 patients were classified into 2 subgroups: lower GI (LGI=50) and upper GI (UGI=36). Clinical suspicion was confirmed in 52% and 66% of patients, respectively, and there was good device agreement between WMC and CMT in 76% and 81% in the LGI and UGI groups, respectively. There was new diagnostic information with the WMC test in 53% of the LGI (P=0.006) and 47% of the UGI group (P=0.001). WMC detected generalized motility disorder in 44 (51%) patients and influenced management in 30% of LGI and 50% of UGI subjects.
WMC confirmed clinical suspicion, provided new diagnostic information, influenced clinical management, and detected many patients with generalized motility disorder. It had good device agreement with conventional tests.
探讨无线动力胶囊（WMC）在疑似胃肠道（GI）动力障碍患者中的诊断价值。
疑似 GI 动力障碍的患者接受侵入性和昂贵的诊断性检查。在这些患者中，WMC 是否提供了有临床价值的信息尚不清楚。
对有动力障碍症状且内镜/影像学检查正常的患者进行 WMC 检测和常规动力检测（CMT）。通过比较 WMC 与 CMT 的设备一致性和新信息，回顾性评估 WMC 的诊断价值。
根据主要症状，86 例患者分为 2 个亚组：下胃肠道（LGI=50）和上胃肠道（UGI=36）。分别有 52%和 66%的患者临床怀疑得到证实，LGI 和 UGI 组中 WMC 和 CMT 的设备一致性分别为 76%和 81%。LGI 组中有 53%（P=0.006）和 UGI 组中有 47%（P=0.001）的患者 WMC 检测出新的诊断信息。WMC 检测到 44 例（51%）患者存在全身性运动障碍，并影响了 30%LGI 和 50%UGI 患者的治疗方案。
WMC 证实了临床怀疑，提供了新的诊断信息，影响了临床管理，并检测到许多患有全身性运动障碍的患者。它与常规检查具有良好的设备一致性。
