Xie X, McGregor M, Dendukuri N
Department of Medicine, I McGill University Health Centre, Montreal, Quebec, Canada.
J Wound Care. 2010 Nov;19(11):490-5. doi: 10.12968/jowc.2010.19.11.79697.
To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs).
A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument.
We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased.
There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated.
在对已报道的随机对照试验（RCT）进行系统评价的基础上，评估负压伤口治疗（NPWT）的疗效。
对相关RCT进行系统的文献检索。使用专门构建的工具评估每项研究结果的可信度。
我们确定了17项RCT，其中5项未被纳入先前的综述或卫生技术评估。对于糖尿病足溃疡（7项RCT），有一致的证据表明与对照治疗相比，NPWT有益。对于压疮（3项RCT），结果相互矛盾。在涉及混合伤口的试验（5项RCT）中，证据令人鼓舞，但质量不足。严重并发症并未增加。
现在有足够的证据表明NPWT是安全的，并且会加速愈合，证明其可用于治疗糖尿病相关的慢性腿部伤口。也有证据表明，尽管质量较差，但其他伤口的愈合可能也会加速。
