Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Cell Res. 2011 Jan;21(1):6-21. doi: 10.1038/cr.2010.170. Epub 2010 Dec 7.
Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.
泛素化作为一种通用的信号标签的作用在 NF-κB 途径中得到了很好的体现，该途径可响应各种刺激调节多种生理和病理过程。在这里，我们综述了泛素化在 NF-κB 信号级联反应的不同步骤中的作用，重点介绍了在不同途径中聚泛素链激活蛋白激酶的机制的最新进展，这些途径都汇聚到 NF-κB。
