Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Strahlenther Onkol. 2011 Jan;187(1):39-44. doi: 10.1007/s00066-010-2151-0. Epub 2010 Dec 10.
To evaluate the therapeutic effect of rehabilitation therapy on radiation-induced dysphagia and trismus in nasopharyngeal carcinoma (NPC) patients after radiotherapy.
43 NPC patients after radiotherapy were included. Patients were randomly assigned to either the rehabilitation group or a control group. Both groups were subjected to routine treatment, while the rehabilitation group also received rehabilitation therapy for 3 months. The severity of dysphagia was assessed using the water swallow test, while trismus was evaluated with the LENT/SOMA score and the interincisor distance (IID). The water swallow test, the LENT/SOMA score, as well as IID for both groups before and after treatment were analyzed and compared.
After treatment, the rehabilitation group displayed a significant improvement in swallowing function, while the control group did not. The efficacy rate (percentage of patients with excellent or effective results) of rehabilitation group was higher than that of control group (77% vs. 43%), and the difference was statistically significant (ϰ(2) = 5.32, p = 0.02). IID pretreatment and posttreatment did not show much difference in the rehabilitation group, while in the control group IID significantly decreased posttreatment (1.1 ± 0.36 cm vs.1.8 ± 0.56 cm, p = 0.001). Although the mean IID in patients of both groups decreased after the 3 month follow-up, the decrease in the rehabilitation group was less than that of the control group (0.19 ± 0.5 cm vs. 0.69 ± 0.56 cm, p = 0.004 ). The efficacy rate of trismus in the rehabilitation group was significantly higher than that of the control group (64% vs. 28%, ϰ(2) = 5.31, p = 0.02).
Rehabilitation training can improve swallow function and slow down the progress of trismus in NPC patients following radiotherapy.
评估康复治疗对鼻咽癌（NPC）患者放疗后放射性吞咽困难和张口困难的治疗效果。
纳入 43 例 NPC 放疗后患者，随机分为康复组和对照组。两组均给予常规治疗，康复组同时接受康复治疗 3 个月。采用饮水试验评估吞咽困难严重程度，LENT/SOMA 评分和牙间距离（IID）评估张口困难。分析并比较两组治疗前后吞咽困难的严重程度、张口困难的 LENT/SOMA 评分和 IID。
治疗后，康复组吞咽功能明显改善，而对照组无明显改善。康复组的疗效（优或有效患者比例）明显高于对照组（77%比 43%），差异有统计学意义（ϰ²=5.32，p=0.02）。康复组治疗前后 IID 差异无统计学意义，而对照组治疗后 IID 明显减小（1.1±0.36cm 比 1.8±0.56cm，p=0.001）。尽管两组患者在 3 个月随访时的 IID 均值均有所下降，但康复组的下降幅度小于对照组（0.19±0.5cm 比 0.69±0.56cm，p=0.004）。康复组的张口困难疗效明显高于对照组（64%比 28%，ϰ²=5.31，p=0.02）。
康复训练可改善 NPC 放疗后患者的吞咽功能，减缓张口困难的进展。
