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口咽吞咽困难患者的行为干预:随机临床试验的系统评价和荟萃分析

Behavioural Interventions in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.

作者信息

Speyer Renée, Cordier Reinie, Sutt Anna-Liisa, Remijn Lianne, Heijnen Bas Joris, Balaguer Mathieu, Pommée Timothy, McInerney Michelle, Bergström Liza

机构信息

Department Special Needs Education, Faculty of Educational Sciences, University of Oslo, 0318 Oslo, Norway.

Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia.

出版信息

J Clin Med. 2022 Jan 28;11(3):685. doi: 10.3390/jcm11030685.

Abstract

OBJECTIVE

To determine the effects of behavioural interventions in people with oropharyngeal dysphagia.

METHODS

Systematic literature searches were conducted to retrieve randomized controlled trials in four different databases (CINAHL, Embase, PsycINFO, and PubMed). The methodological quality of eligible articles was assessed using the Revised Cochrane risk-of-bias tool for randomised trials (RoB 2), after which meta-analyses were performed using a random-effects model.

RESULTS

A total of 37 studies were included. Overall, a significant, large pre-post interventions effect size was found. To compare different types of interventions, all behavioural interventions and conventional dysphagia treatment comparison groups were categorised into compensatory, rehabilitative, and combined compensatory and rehabilitative interventions. Overall, significant treatment effects were identified favouring behavioural interventions. In particular, large effect sizes were found when comparing rehabilitative interventions with no dysphagia treatment, and combined interventions with compensatory conventional dysphagia treatment. When comparing selected interventions versus conventional dysphagia treatment, significant, large effect sizes were found in favour of Shaker exercise, chin tuck against resistance exercise, and expiratory muscle strength training.

CONCLUSIONS

Behavioural interventions show promising effects in people with oropharyngeal dysphagia. However, due to high heterogeneity between studies, generalisations of meta-analyses need to be interpreted with care.

摘要

目的

确定行为干预对口咽吞咽困难患者的影响。

方法

进行系统的文献检索,以检索四个不同数据库(CINAHL、Embase、PsycINFO和PubMed)中的随机对照试验。使用修订后的Cochrane随机试验偏倚风险工具(RoB 2)评估符合条件文章的方法学质量,之后使用随机效应模型进行荟萃分析。

结果

共纳入37项研究。总体而言,发现干预前后有显著的、较大的效应量。为比较不同类型的干预措施,将所有行为干预和传统吞咽困难治疗比较组分为代偿性、康复性以及代偿与康复相结合的干预措施。总体而言,确定行为干预具有显著治疗效果。特别是,在比较康复性干预与无吞咽困难治疗,以及联合干预与代偿性传统吞咽困难治疗时,发现了较大的效应量。在比较特定干预措施与传统吞咽困难治疗时,发现有利于摇头运动、抗阻下颌后缩运动和呼气肌力量训练的显著、较大效应量。

结论

行为干预对口咽吞咽困难患者显示出有前景的效果。然而,由于研究之间存在高度异质性,荟萃分析的概括需要谨慎解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5098/8836405/613fbc93000e/jcm-11-00685-g001.jpg

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