Lichtenstern C, Müller M, Schmidt J, Mayer K, Weigand M A
Klinik für Anaesthesiologie und Operative Intensivmedizin, Universitätsklinikum Giessen und Marburg, Standort Giessen, Rudolf-Buchheim Str. 7, 35392, Giessen, Deutschland.
Anaesthesist. 2010 Dec;59(12):1135-52; quiz 1153-4. doi: 10.1007/s00101-010-1822-7.
Transplantation medicine is an interdisciplinary task and the priority objective is a fast recovery to patient independence. After kidney transplantation the crucial aims are monitoring of transplant perfusion, maintainance of an adequate volume status and avoidance of nephrotoxic medications. Transplantation for patients with advanced chronic liver failure has become more common since the implementation of the model of end stage liver disease (MELD) allocation system which is associated with more complicated proceedings. The essentials of critical care after liver transplantation are monitoring of transplant function, diagnosis of perfusion or biliary tract problems, specific substitution of coagulation factors and hemodynamic optimation due to avoidance of hepatic congestion. Many patients listed for heart transplantation need preoperative intensive care due to impaired heart function. Postoperatively a specific cardiac support with pulmonary arterial dilatators and inotropics is usually necessary. Lung transplantation aims at an improvement of patient quality of life. Postoperative critical care should provide a limitation of the pulmonary arterial pressure, avoidance of volume overload and rapid weaning from the respirator.
移植医学是一项跨学科任务,首要目标是让患者迅速康复并恢复自理能力。肾移植后,关键目标是监测移植肾灌注情况、维持充足的血容量状态以及避免使用肾毒性药物。自从实施终末期肝病(MELD)分配系统以来,晚期慢性肝功能衰竭患者的移植手术变得更加普遍,而该系统与更为复杂的手术过程相关。肝移植后重症监护的要点包括监测移植肝功能、诊断灌注或胆道问题、特异性补充凝血因子以及通过避免肝淤血来优化血流动力学。许多等待心脏移植的患者由于心功能受损需要术前重症监护。术后通常需要使用肺动脉扩张剂和强心剂进行特异性心脏支持。肺移植旨在改善患者生活质量。术后重症监护应限制肺动脉压力、避免容量超负荷并尽快撤机。