Department of Obstetrics and Gynecology, University of Miami, Miami, Florida, USA.
Am J Perinatol. 2011 May;28(5):355-60. doi: 10.1055/s-0030-1270117. Epub 2010 Dec 6.
We sought to determine if outcomes of nulliparous twin pregnancies differ based on maternal age. Nulliparous women with current twin pregnancies were identified from a database of women enrolled for outpatient nursing surveillance. Data were stratified into four groups by maternal age: less than 20, 20 to 34, 35 to 39, and greater than or equal to 40 years. Maternal and neonatal outcomes for women less than 20, 35 to 39, and 40 or more were compared with 20- to 34-year-old controls using Kruskal-Wallis, Mann-Whitney, and Pearson chi-square analyses. We analyzed 2144 nulliparous twin pregnancies. Patients ≥35 years (34 to 39, 78.5% or ≥40, 85.9%) were more likely to have cesarean deliveries compared with controls 20 to 34 years old (71.2%). Women aged 35 to 39 were less likely to deliver at <37 weeks, and women in the ≥40 group were less likely to deliver at <35 weeks due to spontaneous preterm labor compared with the controls. Neonates born to women aged 35 to 39 had a greater gestational age at delivery and larger average birth weight than controls. Maternal and neonatal outcomes were not adversely influenced by advanced maternal age in nulliparous women carrying twin gestations.
我们试图确定初产妇的双胎妊娠结局是否因母亲年龄而异。从接受门诊护理监测的妇女数据库中确定了当前怀有双胎妊娠的初产妇。将数据按母亲年龄分为四组：小于 20 岁、20-34 岁、35-39 岁和大于等于 40 岁。使用 Kruskal-Wallis、Mann-Whitney 和 Pearson 卡方分析比较小于 20 岁、35-39 岁和 40 岁或以上的妇女与 20-34 岁对照组的产妇和新生儿结局。我们分析了 2144 例初产妇的双胎妊娠。与 20-34 岁的对照组相比，年龄≥35 岁的患者（34-39 岁，78.5%或≥40 岁，85.9%）更有可能进行剖宫产。与对照组相比，年龄在 35-39 岁的产妇更不可能在<37 周分娩，而年龄在≥40 岁的产妇更不可能在<35 周时因自发性早产而分娩。与对照组相比，年龄在 35-39 岁的产妇分娩时的胎龄更大，平均出生体重更大。在携带双胎妊娠的初产妇中，母亲年龄的增加并没有对产妇和新生儿结局产生不利影响。
