Nagao H, Morimoto T, Takahashi M, Habara S, Nagai H, Matsuda H
Department of Pathology for the Handicapped, Faculty of Education, Ehime University, Japan.
Neuropediatrics. 1990 May;21(2):79-82. doi: 10.1055/s-2008-1071466.
Twelve patients with typical absence seizures, aged five years two months to 10 years, were examined to clarify the circadian rhythm of 3 c/s spike-and-wave paroxysms (s-w paroxysms), by means of video-electroencephalography with telemetry. S-w paroxysms combined with clinical symptoms and continuing for more than four seconds were fewer during the afternoon than the morning and, moreover, during sleep. The correlation ratio between the frequency and duration of s-w paroxysms was r = -0.74, which was statistically significant (p less than 0.02). The duration of s-w paroxysms evoked by hyperventilation or photic stimulation did not differ from that of spontaneous s-w paroxysms. The s-w paroxysms were shorter and deformed in sleep. Therefore, the observation of typical absence seizures during the morning should be regarded as important. In patients with modified s-w paroxysms during sleep, it is important that electroencephalographic recording with stimulation, such as hyperventilation, is performed sufficiently.
对12例年龄在5岁2个月至10岁的典型失神发作患者进行了检查，通过遥测视频脑电图来明确3次/秒棘慢波阵发（棘慢波阵发）的昼夜节律。与临床症状相关且持续超过4秒的棘慢波阵发在下午比上午少，而且在睡眠期间也较少。棘慢波阵发的频率与持续时间之间的相关比为r = -0.74，具有统计学意义（p小于0.02）。过度换气或光刺激诱发的棘慢波阵发的持续时间与自发性棘慢波阵发的持续时间没有差异。棘慢波阵发在睡眠中较短且形态异常。因此，上午对典型失神发作的观察应被视为重要。对于睡眠期间棘慢波阵发有改变的患者，充分进行诸如过度换气等刺激下的脑电图记录很重要。
